CHE532 Syllabus

Spectrometric Identification of Organic Molecules
CHE 532 SPECTROMET ID-ORG COMPND 2.0
Prereq: CHE 231 and CHE 232.

Fall 2009

Course Description:  CHE532 aims to impart to the student proficiency in the use of spectrometric data to infer chemical structure and dynamics. This problem-based instruction involves nuclear magnetic resonance, ultraviolet and infrared spectroscopies, mass spectrometry and differential chemical reactivity to determine the structure of organic compounds. There will be discussions of the molecular symmetry and of chemical and physical methods for separation of mixtures of organic compounds. This is not a lab course, so there will be no real time interaction with instrumentation.

Instructor:  Arthur Cammers

Office: CP-349 Ph: 323-8977

E-mail: a.cammers@uky.edu        This is the  best way to contact me. Put chem 532" in the subject line.  

Office Hours: by appointment, or just drop by

Required Text: Introduction to Spectroscopy, ed. 4. Pavia, Lampman, Kriz, & Vyvyan.

Info will be available on the web at http://www.chem.uky.edu/courses/che532/

When and Where: Sec 001, TR 09:30AM-10:20AM LEC CP 345

Grade Assignment

• 1/3 of your final grade will be determined by 6-8 homework assignments.  These assignments are to be your own work.  
• 1/3 of your final grade will be determined by your performance on the midterm exam.  At midterm you will be issued a midterm grade. This grade is nominal  only for self-evaluation. The midterm grade will perhaps not be evaluated at the mathematical median of the total possible points earned.
  
• 1/3 of your final grade will be determined by your performance on the final exam.  
  
• I will be vocal during the semester about whether the class is meeting my expectations. I will also pay attention to individuals in this regard. I really want you all to do well.

There are graduate as well as undergraduate students in this course.  The graduate school does not permit \\"grades to be given.  In the interest of fairness, a uniform grading policy was adopted.

• August 26 – Wednesday - First day of classes
• Overview
• fermions, bosons and Pauli exclusion / spectroscopy / spectrometry / electromagnetic spectrum / resonance / the time constant / molecular motion / quantum theory /
  
• standards for characterization to publish a new organic compound
• symmetry for spectroscopy
• diastereotopic // enantiotopic
  
• Determination of Composition, Empirical Formula and Molecular Weight
  
• (chapter 1)
  
• degrees of unsaturation

• IR
• (chapter 2)
  
• Beer-Lambert Law
• basic theory
  
• instrumentation
  
• features
• use for structure elucidation

• 1D ¹H NMR spectrometry
• (chapter 3, p 105-130)
• basic theory
• instrumentation
  
• chemical shift
• shielding
• atom hybridization
  
• magnetic anisotropy
• dynamics
• Assignment 1.

• 1D ¹H NMR
• (chapter 3, p 130-176)
• spectral features
• splitting
  
• coupling constants
• molecular conformation
• Assignment 2.
• 1D ¹H NMR
• (chapter 5)
• spin-spin coupling
  
• splitting patterns, AB, ABX etc.
  
• magnetic equivalence
  
• molecular conformation
• molecular configuration
  

• Assignment 3.

• 1D ¹³C NMR spectrometry
• (chapter 4)
• differences from proton spectrometry
• shielding, magnetic anisotropy and atom hybridization
• features, nOe
  
• chemical shift
• coupling constants

• Midterm Exam, date to be announced.
• October 19 – Monday - Midterm of 2009 Fall Semester

• 1D ¹H NMR
• (chapter 6)
• Dynamics
• VT NMR
• Absolute configuration
  
• nOe

• Heteronuclear 1D NMR spectrometry
  
• differences from proton spectrometry

• Correlative NMR spectrometry
• (chapter 10)
• basic theory
• use for structure elucidation
  

• Assignment 4.
• Mass spectrometry
• (chapter 8)
• basic theory
  
• instrumentation
  
• features
• use for structure elucidation

• Assignment 5.
• Assignment 6.

• UV and Fluorescence spectroscopy
  
• (chapter 7)
• basic theory
  
• instrumentation
  
• features
• structure elucidation and molecular interactions
  

• December 11 – Friday - Last day of classes
• Final Exam, date to be announced.