CHE535 Synthetic Organic Chemistry

Using the Library to Effective Search the Chemical Lecture

Purpose: to advance your ability to use chemical knowledge to communicate, to publish and to do assignments in CHE535. If you have any problems with anything below. Let me know. You can even bring your laptop to my office. I am willing to help at this level if you need it.

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Chemical Structure Drawing Program

See me if you can't draw structures on a computer and include them in a text document.
A very good, free utility is Isis Draw.
Local Download

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VPN

Fakes your presence at UK, entirely legal.
You can be at home and use databases that demand that you are at the University. If you have a problem downloading or installing this utility; let me know I can likely help.
How to get.
http://download.uky.edu/

or Download it locally from the CHE535 site.  Select save target as or something like that from your browser.

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Endnote

Efficient inclusion of references in a text document. PC and Mac. After you learn to use this utility, you will feel challenged in its absence.
http://download.uky.edu/

Here is a synthetic database. It contains Endnote references to many review articles. Download the file to the directory that you keep for this course. When you open it with Endnote the program will tell that it needs to convert the file to a more recent format. 

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Web of Science

UK library Find database
Science Citation Index web ISI
A time machine. Very powerful literature searching utility. If you are doing this from home. You will need the VPN client running. You can probably get away with establishing an internet connection from the dorms. 

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Scifinder Scholar

Structure-based searching

How to get.

http://www.uky.edu/Libraries/record.php?lir_id=576

or Download Scifinder locally from the CHE535 site.  Select save target as or something like that from your browser.

The site.prf file needs to be present in the same directory in which you have the executable file. The installation process will put the executable file in a particular directory.

An example of how one would use SciFinder in a synthetic problem.

Open Scifinder
Let's say that you had to develop a paper synthesis of the following molecule where n=0 and n=1.

 
Let's list the elements of molecular complexity in the structure above so we can direct our synthetic effort.

Focus on easy heteroatom-based disconnections.
Draw substructures. Start with an enantiospecific structure of the 1,3-diamino-2-cyclpentanol.

We found that structures with absolute stereochemistry related to the five ring diamino alcohol were extremely rare, whereas those related to the six-ring diamino alcohol were extremely common. 

 Play with the database utility to learn to use it.

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Beilstein Commander

Structure-based searching
How to get
http://www.uky.edu/Libraries/page.php?lweb_id=414

 How to use.
Open Beilstein commander.

You are going to have to choose the structure drawing program that you want to use with the Commander. ISIS draw isa a common choice. The commander also comes with a structure drawing program. Explore the five ring diamino alcohol above. We found a structure that was not in the set of hits found using Scifinder scholar. The two databases do not have the same information.

Again play with the utility to learn to use it.