Practice Problem Two

You will not submit this for credit.
Examine our recent notes on cation cyclization.
See the literature cited.

Then retrosynthetically analyze the following target molecules with the cation cyclization retron. Perhaps the first retro arrow that gets you there will be cation cyclization. When you use the cation cyclization you may stop your retrosynthesis. This exercise is a good one in order to apply more than one retro using similar methodology. This will test your command over the chemistry.




HINTS: Compound A is similar to one of the examples we did in class. For molecule B think symmetry. For molecule C think about Friedel-Crafts acylation. For molecule D think about electrophillic aromatic substitution as a component of the cyclization.

Try the problems before you look at the possible answers

Answers