THE UNIVERSITY OF KENTUCKY
DEPARTMENT OF CHEMISTRY
CHE 633, Physical Organic Chemistry
Course Description: An advanced presentation of the mechanisms of organic reactions, the experimental methods used to elucidate these mechanisms, and the effect of changing structure and reaction conditions on the reactivity of organic molecules.
Prerequisites: CHE 538.
This course has not been taught recently, so no current syllabus is available. However, we have outlined some tentative plans for this course:
Probably Lowry and Richardson (Harper and Row) "Mechanism and Theory in Organic Chemistry" but supplemented with primary literature and other texts.
Topics currently being considered:
- Structure-Reactivity Relationships,
- Kinetic-Equilibrium Correlations
- Acidity Functions
- Effects of Solvation and Ion Pairing on Organic Reactions
- Use of Kinetic Modeling for Mechanistic Analysis
- ESR and CIDNP Information in Diagnosis of Radical Mechanisms
- Stereochemical Probes of Mechanism
- Interpretation of Isotope Effects
- Predictive Power of MO and Force Field Calculations
- Problems Involving Biological Reaction Mechanisms
- High Temperature Reactions
- Correlations using Cyclic Voltammetry and Other Electrochemical Methods
- Use of Pulse Radiation Methods
- Photochemical Mechanisms
- Maybe a few environmentally relevant reactions
- Any hot new topics of recent interest
The minimum penalty for cheating is a grade of "E" for this course.
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This page was last updated Nov. 01, 2004.