| |  Honors and Awards - Phi Beta Kappa Honorary Society, 1968
- Phi Kappa Phi Honorary Society, 1967
- NIH Biomedical Science Research Award, 1972
- Graduate School Research Award (Duke University), 1972
- NIH Postdoctoral Fellowship, 1974
- University of Kentucky Research Foundation Faculty Research Award, 1979
- Awarded University of Kentucky Research Professorship, 1980 81
- Appointed to Biophysics and Biophysical Chemistry Study Section A of the National Institutes of Health (NIGMS), Spring 1980 Meeting
- Appointed to National Institute of Health Site Visit Study Section, Summer 1980
- Invited Speaker, Gordon Research Conference on Magnetic Resonance in Biology and Medicine, 1980
- Consultant, National Institute on Aging, NIH Site Visit, "Alzheimer's Disease Center," May, 1987
- Consultant, National Heart, Lung and Blood Institute, NIH Site Visit, "Comprehensive Sickle Cell Disease Center," May, 1987
- Special Faculty Grant, 1988 1990
- Editorial Board Member, Journal of Membrane Science, 1989 present
- Finalist, College of Arts and Sciences Distinguished Professorship, 1990, 1991
- Dow Chemical Distinguished Lectureship, University of Detroit, 1995
- The Honorable Order of Kentucky Colonels, 1995
- Consultant, National Institute on Aging, NIH Reverse Site Visit on "b-Amyloid Program Project," 1996
- Recipient, Distinguished University Scientist Award from the Kentucky Academy of Science, 1996
- Consultant, National Science Foundation, Small Business Investigative Research Panel, 1996
- Consultant, national Aeronautics and Space Administration, Shuttle Experiment Panel, 1997
- Recipient, William B. Sturgill Award for Graduate Education, 1997
- Recipient, Southern Chemist Award from the American Chemical Society, Memphis Section, 1997
- Recipient, Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring, Presented by President Clinton in the White House, 1998.
 Professor Butterfield's Membrane Science Activities Free radical oxidative stress is a hallmark of aging and age-related neurodegenerative disorders such as Alzheimer's disease (AD). Such oxidative stress is manifested in neurons by protein oxidation, lipid peroxidation, reactive oxygen species (ROS) production, mitochondrial dysfunction, and functional impairment of key transmembrane transport proteins, among many others. Our laboratory studies these and other aspects of oxidative stress in brain membranes using a variety of techniques, including magnetic resonance (both EPR and NMR), fluorescence, chemiluminescence, Western blotting, HPLC analysis, enzyme kinetics, etc. Our group has described how oxidative stress associated with amyloid b-peptide (Ab), a 42-amino acid peptide deposited in AD brains, leads to neurotoxicity and how various antioxidants can modulate or prevent this oxidative stress and neuronal death. For example, the figure, illustrating results from confocal laser fluorescence microscopy, shows how Ab leads to ROS formation in neurons, but the free radical antioxidant vitamin E markedly inhibits this oxidation. Insight into the molecular basis for and potential therapeutic interventions in aging and age-related neurodegenerative disorders is envisaged from our research. Ab(1-42) Added to Neurons Induces ROS That Are Blocked by Vitamin E |
