D. Allan Butterfield's Publications, 1995-Present

Research Publications (Total Number of Publications 448)
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448. W.O. Opii, E. Head, D.M. Turner, W.M. Pierce and D. A. Butterfield, "Proteomic Expression Analysis of Brain Proteins Form Dementia Free Nonagenarians: Relevance to Successful Aging and Alzheimer's Disease," manuscript in preparation (2009). 447. P. Jungsuwadee, Y. Chen, L. Chaiswing, T.D. Oberly, D. A. Butterfield, D.K. St. Clair and M. Vore, "Mrp1 Characterization of Cardiac Mitochondria Following Adrimycin Injection in C57BL/6 Mice," submitted for publication (2009). 446. M. Perluigi, R. Sultana, G. Cenini, F. Di Domenico, M. Memo, W.M. Pierce, R. Coccia, and D. A. Butterfield, "Redox Proteomics Identification of HNE-Modified Brain Proteins in Alzheimer's Disease: Role of Lipid Peroxidation in Alzheimer's Disease Pathogenesis," Proteomics--Clinical Applications, in press (2009). 445. L.R. Ribeiro, M.R. Fighera, M.S. Oliveira, A.F. Furian, L.M. Rambo, A.P. de Oliveira Ferreira, A.L. Lopes Saraiva, M.A. Souza, F.D. Lima, D.V. Magni, R. Dezengrini, E. F. Flores, D. A. Butterfield, J. Ferreira, A.R. Soares dos Santos, C.F. Mello, L.F. Freire Royes, “Methylmalonate-induced Seizures Are Attenuated in Inducible Nitric Oxide Synthase Knockout Mice,” International Journal of Developmental Neuroscience, in press (2009). 444. J. Owen, F. Di Domenico, R. Sultana, M. Perluigi, C. Cini, W. Pierce, and D. A. Butterfield, “Proteomics-determined differences in the Concanavalin-A fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer’s disease and mild cognitive impairment: Implications for progression of AD," Journal of Proteome Research, in press (2009). 443. F. Di Domenico, M. Perluigi, C. Foppoli, C. Blarzino, R. Coccia, F. De Marco, D. A. Butterfield, and C. Cini, "Protective Effect of Ferulic Acid Ethyl Ester Against Oxidative Stress Mediated by UVB Irradiation in Human Epidermal Melanocytes," Journal of Cellular and Molecular Medicine, in press (2009). 442. T.T. Reed, W.M. Pierce, D.M. Turner, W.R. Markesbery, and D. A. Butterfield, "Proteomic Identification of Nitrated Brain Proteins in Early Alzheimer’s Disease Inferior Parietal Lobule," Journal of Cellular and Molecular Medicine, in press (2009). 441. F. Di Domenico, G. Cenini, R. Sultana, M. Perlugi, D. Uberti, M. Memo, and D. A. Butterfield, "Glutathionylation of the Pro-apoptotic Protein p53 in Alzheimer's Disease Brain: Implications for AD Pathogenesis," Neurochemical Research, in press (2009). 440. M.A. Ansari, H. Mohmmad Abdul, G. Joshi, W. O. Opii, and D. A. Butterfield, “Protective Effect of Quercetin in Primary Neurons Against A?(1-42): Relevance to Alzheimer's Disease,” Journal of Nutritional Biochemistry, in press (2009). 439. R. Sultana, M. Piroddi, F. Galli, and D. A. Butterfield, “Protein Levels and Activity of Some Antioxidant Enzymes in Hippocampus of Subjects with Amnestic Mild Cognitive Impairment,” Neurochemical Research, in press (2009). 438. D. A. Butterfield and M.T. Butterfield, “The Amyloid b-Peptide (1-42)-Associated Free Radical Oxidative Stress Model for Neurodegeneration in Alzheimer’s Disease Brain,” in Amyloid Toxicity (M. Kindy, ED.), Landes Bioscience, Georgetown, TX, in press (2009). 437. R. Sultana, T. Reed, and D. A. Butterfield, “Detection of 4-Hydroxy-2-Nonenal- and 3-Nitrotyrosine-Modified Proteins Using a Proteomics Approach ,” in Two Dimensional Electrophoresis Protocols (D. Sheehan and R. Tyther, Eds.), Humana Press, Totowa, NJ, in press (2009). 436. D. A. Butterfield and H. Mohmmad-Abdul, "Lipids in Alzheimer's Disease Brain," Handbook of Neurochemistry, in press (2009). 435. V. Calabrese, R. Ientile, C. Mancuso, A. M. Giuffrida Stella and D. A. Butterfield, "Nutritional Redox Homeostasis and Cellular Stress Response: Differential Role of Homocysteine and Acetylcarnitine," in Dietary Modulation of Cell Signaling Pathways, L. Packer and C. Surh, Eds., CRC Press, Boca Raton, FL, in press (2009). 434. R. Sultana, H. F. Poon and D. A. Butterfield, "Redox Proteomics Identification of Oxidatively Modified Proteins in Alzheimer's Disease Brain and in Brain from a Rodent Model of Familial Parkinson's Disease," in Progress in Alzheimer's Disease and Parkinson's Disease (A. Fisher, I. Hanin, M. Memo and F. Stocchi, Eds.), Springer, New York, in press (2009). 433. V. Calabrese, G. Pennisi, M. Calvani, D. A. Butterfield and C. Mancuso, "Heme Oxygenase as Therapeutic Funnel in Nutritional Redox Homeostasis and Cellular Stress Response: Role of Acetylcarnitine," in Biology of Heat Shock Proteins, Ed. by C. Richter-Landsberg, Elsevier Press, Amsterdam, in press (2009). 432. A. M. Giuffrida Stella, D. A. Butterfield and V. Calabrese, "Gene Regulation," in Developmental and Aging Changes in the Nervous System, part of The Handbook of Neurochemistry and Molecular Biology, (R. Perez-Polo and S. Rossner, Eds.), Kluwer Academic Press, New York, in press (2009). 431. V. Calabrese, C. Mancuso, C. Cornelius, M.S. Calafato, D. A. Butterfield, A.T. Kinkova-Kostova, and E. Rizzarelli, “Reactive Nitrogen Species and Cellular Stress Tolerance in Aging and Neurodegeneration: Role of Vitagenes,” Free Radical Pathophysiology, in press (2009). 430. T.T. Reed, J. Owen, W.M. Pierce, A. Sebastian, P.G. Sullivan, and D.A. Butterfield, "Proteomic Identification of Nitrated Brain Proteins in Traumatic Brain Injured Rats Treated Post-Injury with Gamma-Glutamylcysteine Ethyl Ester: Insights into the Role of Glutathione Elevation as a Potential Therapeutic Strategy for Traumatic Brain Injury," Journal of  Neuroscience Research 87, 408-417 (2009). 429. R.A. Sowell, J.B. Owen and D. A. Butterfield, "Proteomics in Animal Models of Alzheimer's and Parkinson's Diseases," Aging Research Reviews 8, 1-17 (2009). 428. D. A. Butterfield and W. O. Opii, "Mitochondrial Dysfunction in Nervous System Injury," in The New Encyclopedia of Neuroscience, L. Squire, T. Albright, F. Bloom, F. Gage and N. Spitzer, Eds., Elsevier, Oxford, Encyclopedia of Neuroscience 5, 887-984 (2009). 427. D. A. Butterfield, “An Overview of Biofunctional Membranes for Tunable Separations, Metal-ion Capture, and Enzyme Catalysis Based on Research from the Laboratories of Allan Butterfield and Dibakar Bhattacharyya,” Separation Science and Technology 43 , 3942-3954 (2008). 426. R. Sultana, M. Piroddi, F. Galli, and D. A. Butterfield, "Protein Levels and Activity of Some Antioxidant Enzymes in Hippocampus of Subjects with Amnestic Mild Cognitive Impairment and Age-Matched Controls," Neurochemical Research 33, 2540-2546 (2008). 425. J. B. Owen, W.O. Opii, C. Ramassamy, W.M. Pierce, and D. A. Butterfield, “Proteomic Analysis of Brain Protein Expression Levels in NF-k-B p50 -/+ Homozygous Knockout Mice,” Brain Research 1240, 22-30 (2008). 424. H. Mohmmad Abdul, R. Sultana, D.K. St. Clair, W.R. Markesbery and D. A. Butterfield, "Oxidative Damage in Brain from Human Mutant APP/PS-1 Double Knock-In Mice as a Function of Age," Free Radical Biology and Medicine 45, 1420-1425 (2008). 423. C.D. Aluise, R.A. Sowell, and D. A. Butterfield, “Peptides and Proteins in Plasma and Cerebrospinal Fluid as Biomarkers for the Prediction, Diagnosis, and Monitoring of Therapeutic Efficacy of Alzheimer's Disease,” Biochimica et Biophysica Acta 1782, 549-558 (2008). 422. G. Cenini, R. Sultana, M. Memo, and D. A. Butterfield, “Effects of Oxidative and Nitrosative Stress in Brain on p53 Proapoptotic Protein in Amnestic Mild Cognitive Impairment and Alzheimer Disease,” Free Radical Biology & Medicine 45, 81-85 (2008). 421. R. Sultana, S.F. Newman, and D. A. Butterfield, "Redox Proteomics: Applications to Age-Related Neurodegenerative Disorders," in Proteomics of the Nervous System, H.G. Nothwang and S.E. Pfeiffer, Eds., Wiley-VCH Verlag GmbH & Co., Weinheim, Germany, pp. 253-269 (2008). 420. C. Cenini, R. Sultana, M. Memo, and D. A. Butterfield,“Elevated Levels of p53 and Its Oxidative Modification by HNE in Brain from Subjects with Mild Cognitive Impairment and Alzheimer’s Disease,” Journal of Cellular and Molecular Medicine 12, 987-994 (2008). 419. R. Sultana and D. A. Butterfield, "Redox Proteomics Studies of In Vivo Amyloid Beta-Peptide Animal Models of Alzheimer's Disease: Insight into the Role of Oxidative Stress," Proteomics--Clincal Applications 2: 685-696 (2008). 418. D. A. Butterfield and R. Sultana, "Redox Proteomics: Understanding Oxidative Stress in the Progression of Age-Related Neurodegenerative Disorders," Expert Reviews of Proteomics 5, 157-160 (2008). 417. E.G. Oesterling, C. Nitin, X. Arzuaga, D. A. Butterfield, L.G. Bachas, and B. Hennig, “Alumina Nanoparticles Induce Expression of Endothelial Cell Adhesion Molecules,” Toxicology Letts. 178, 160-166 (2008). 416. P. Sompol, W. Ittarat, J. Tangpong, Y. Chen, I. Doubinskaia, I. Batinic-Haberle, H. Mohmmad Abdul, D.A. Butterfield, and D.K. St. Clair, “A Neuronal Model of Alzheimer’s Disease: An Insight into the Mechanisms of Oxidative Stress-Mediated Mitochondrial Injury,” Neuroscience 153, 120-130 (200 415. S.A. Farr, K.A. Yamada, D. A. Butterfield, H. Mohmmad Abdul, L. Xu, N.E. Miller, W.A. Banks, J.E. Morley, “Obesity and Hypertriglyceridemia Produce Cognitive Impairment,” Endocrinology 149, 2628-2636 (2008). 414. V. Calabrese, C. Mancuso, R. Ientile, A.M. Giuffrida Stella and D. A. Butterfield, "Redox Homeostasis and Cellular Stress Response in Aging and Neurodegeneration," in Free Radicals in Biology and Medicine, Y.-J Surh, Z. Dong, E. Cadenas, and L. Packer, Eds., CRC Press, Boca Raton, FL, pp. 229-249 (2008). 413. P. Mecocci, E. Mariani, M.C. Polidori, K. Hensley and D. A. Butterfield, “Antioxidant Agents in Alzheimer’s Disease,” Central Nervous System Agents in Medicinal Chemistry 8, 48-63 (2008). 412. M.A. Brito, S. Lima, A. Fernandes, AS. Falcao, R.F. Silva, D. A. Butterfield and D. Brites, “Bilirubin Injury to Neurons: Contribution of Oxidative Stress and Rescue by Glycoursodeoxycholic Acid,” Neurotoxicology 29 259-269 (2008). 411. T. Reed, M. Perluigi, R. Sultana, W.M. Pierce, D.M. Turner, R. Coccia, W.R. Markesbery, and D. A. Butterfield, “Redox Proteomic Identification of 4-Hydroxy-2-Nonenal-Modified Proteins in Amnestic Mild Cognitive Impairment: Insight into the Role of Lipid Peroxidation in the Progression and Pathogenesis of Alzheimer’s Disease,” Neurobiology of Disease 30 107-120 (2008). 410. M.L. Bader Lange, G. Cenini, M. Piroddi, H. Mohmmad Abdul, R. Sultana, F. Galli, M. Memo, and D. A. Butterfield, “Loss of Phospholipid Asymmetry and Elevated Protein Levels in Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease,” Neurobiology of Disease  29, 456-464 (2008). 409. R. Sultana, T. Reed and D. A. Butterfield, "Redox Proteomics and Metabolic Proteins in Brain of Subjects with Alzheimer’s Disease, Mild Cognitive Impairment, and Models Thereof," in Neural Degeneration and Repair Gene Expression Profiling, Proteomics, Glycomics and Systems Biology, H.W. Muller, Ed., Wiley/VCH Publishers, Heidelberg, pps. 181-207 (2008). 408. R. Sultana and D. A. Butterfield, “Slot Blot Analysis of 3-Nitrotyrosine-Modified Brain Proteins,” Methods of Enzymology 440, 309-316 (2008). 407. D. A. Butterfield and R. Sultana, “Identification of 3-Nitrotyrosine-Modified Brain Proteins by Redox Proteomics,” Methods of Enzymology 440, 295-308 (2008). 406. J. Tangpong, P. Sompol, M. Vore, W. St. Clair, D. A. Butterfield, and D.K. St. Clair, “Tumor Necrosis Factor Alpha-Mediated Nitric Oxide Production Enhances Maganese Superoxide Dismutase Nitration and Mitochondrial Dysfunction in Primary Neurons: An Insight into the Role of Glial Cells,” Neuroscience, 151, 622-629 (2008). 405. M. A. Brito, A. I. Rosaa, A. S. Falcaoa, A. Fernandesa, F. Rui, M. Silvaa, D. A. Butterfield and D. Brites, "Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells," Neurobiology of Disease 29, 30-40 (2008). 404. R. Sultana and D. A. Butterfield “Alterations of Some Membrane Transport Proteins in Alzheimer’s Disease: Role of Amyloid Beta-Peptide,” Molecular BioSystems, 4, 36-41 (2008). 403. W. O. Opii, G. Joshi, E. Head, N. W. Milgram, B. A. Muggenburg, J. B. Klein, W. M. Pierce, C. W. Cotman and D. A. Butterfield, "Proteomic Identification of Brain Proteins in the Canine Model of Human Aging Following a Long-Term Treatment with Antioxidants and Program of Behavioral Enrichment: Relevance to Alzheimer's Disease," Neurobiology of Aging 29, 51-70 (2008). 402. H.F. Poon, N.A. Shreve, A. Veicsteinas, V. Calabrese, F. Esposito, and D. A. Butterfield, “Exercise-mediated alteration of protein redox state in plasma: a possible stimulant fro hermetic response,” Sports Sci. Health 2, 76-79 (2007). 401. D. A. Butterfield and R. Sultana, “Proteomics Analysis in Alzheimer’s Disease: New Insights into Mechanisms of Neurodegeneration,” Handbook of Neurochemistry and Molecular Neurobiology, 3 rd Edition: Degenerative Diseases of the Nervous System, A. Lajtha, Ed., and M.B.H. Youdim, P. Riederer, S.A. Mandel, and L. Battistin, Volume Eds., Springer, New York, pps. 233-252 (2007). 400. C. Mancuso, T. E. Bates, D. A. Butterfield, S. Calafato, C. Cornelius, A.T. Dinkova Kostova, and V. Calabrese, “Natural Antioxidants in Alzheimer’s Disease,” Expert Opinion in Investigational Drugs 16, 1921-1931 (2007). 399. V. Calabrese, C. Mancuso, M. Calvani, E. Rizzarelli, D. A. Butterfield and A.M. Giuffrida Stella, “Nitric Oxide in the Nervous System: Neuroprotection vs. Neurotoxicity,” Nature Reviews of Neuroscience 8, 766-775 (2007). 398. D. A. Butterfield and R. Sultana, “Redox Proteomics Identification of Oxidatively Modified Brain Proteins in Alzheimer’s Disease and Mild Cognitive Impairment: Insights into the Progression of this Dementing Disorder,” Journal of Alzheimer’s Disease 12, 61-72 (2007). 397. R. Sultana, T. Reed, M. Perluigi, R. Coccia, W. M. Pierce, and D. A. Butterfield, “Proteomic Identification of Nitrated Brain Proteins in Amnestic Mild Cognitive Impairment: A Regional Study,” J. Cell. Molec. Med. , 11, 839-851 (2007). 396. D. A. Butterfield, Tanea Reed, Shelley F. Newman and Rukhsana Sultana, “ Roles of Amyloid β-Peptide-Associated Oxidative Stress and Brain Protein Modifications in the Pathogenesis of Alzheimer’s Disease and Mild Cognitive Impairment,” Free Radical Biology & Medicine, 43, 658-677 (2007). 395. C. F. Mello, R. Sultana, M. Piroddi, J. Cai, W. M. Pierce, J. B. Klein, D. A. Butterfield, "Acrolein induces selective protein carbonylation in synaptosomes," Neuroscience, 147, 674-679 (2007). 394. Y. Chen, P. Jungsuwadee, M. Vore, D. A. Butterfield, and D.K. St. Clair, "Collateral Damage in Cancer Chemotherapy: Oxidative Stress in Nontargeted Tissues," Molecular Interventions 7, 145-154 (2007). 393. R. Sultana and D. A. Butterfield, "Redox Proteomics Analysis of Oxidatively Modified Brain Proteins in Alzheimer's Disease and Mild Cognitive Impairment: Insights into the Progression of this Dementing Disorder," in Clinical Proteomics: From Diagnosis to Therapy, J. Van Eyk and M. Dunn, Eds., Wiley VCH Publishers, Weinheim, 381-401, 2007. 392. W. Opii, V. Nukala, R. Sultana, J. Pandya, K. Day, M. Merchant, J. Klein, P. Sullivan, and D. A. Butterfield, “Proteomic Identification of Oxidized Mitochondrial Proteins Following Experimental Brain Injury,” Journal of Neurotrauma, 24, 772-789 (2007). 391. R. Sultana, D. Boyd-Kimball, J. Cai, W.M. Pierce, J.B. Klein, M. Merchant, and D. A. Butterfield, “Proteomics Analysis of the Alzheimer’s Disease Hippocampal Proteome,” Journal of Alzheimer’s Disease, 11, 153-164 (2007). 390. M. Piroddi, I. Depunzio, V. Calabrese, C. Mancuso, C.M. Aisa, L. Binaglia, A. Minelli, D. A. Butterfield, and F. Galli, “Oxidatively-modified and glycated proteins as candidate pro-inflammatory toxins in uremia and dialysis patients,” Amino Acids, 32, 573-592 (2007). 389. V. Calabrese, E. Guagliano, M. Sapienza, M. Panebianco, S. Calafato, E. Puleo, G. Pennisi, C. Mancuso, D. A. Butterfield and A. M. Giuffrida Stella, "Redox Regulation of Cellular Stress Response in Aging and Neurodegenerative Disorders: Role of Vitagenes," Neurochem. Res.32, 757-773 (2007). 388. R. Sultana and D. A. Butterfield, "Regional Expression of Key Cell Cycle Proteins in Brain from Subjects with Amnestic Mild Cognitive Impairment," Neurochemical Research32, 655-662 (2007). 387. S. Newman, R. Sultana, M. Perluigi, R. Coccina, J. Cai, W. Pierce, J. Klein, and D. A. Butterfield, “Increased S-Glutathionylated Proteins in the Alzheimer’s Disease Inferior Parietal Lobule: A Proteomics Approach,” J Neurosci. Res. 85, 1506-1514 (2007). 386. V. Calabrese, C. Mancuso, G. Scapagnini, A. Ravagna, M. Perluigi, C. Cini, C. De Marco, D. A. Butterfield and A. M. Giuffrida Stella, "In Vivo Induction of Heat Shock Proteins in the Substantia Nigra Following L-DOPA Administration is Associated with Increased Activity of Mitochondrial Complex I and Nitrosative Stress in the Rat: Regulation by Glutathione Redox State," J. Neurochem., 101, 709-717 (2007). 385. D. A. Butterfield , T. Reed, M. Perluigi, Carlo De Marco, Raffaella Coccia, J,N. Keller, W.R. Markesbery, and R. Sultana, “Elevated Levels of 3-Nitrotyrosine in Brain from Subjects with Amnestic Mild Cognitive Impairment: Implications for the Role of Nitration in the Progression of Alzheimer’s Disease,” Brain Res. 1148, 243-248 (2007). 384. C. F. Mello, M. A. Rubin, R. Sultana, S. Barron, J. M. Littleton and D. A. Butterfield, "Difluoromethylornithine (DFMO) Prevents Protein Oxidation Induced by Neonatal Ethanol Exposure in the Hippocampus of Young Rats," Alcoholism: Clinical and Experimental Research, 31, 887-894 (2007). 383. W. O. Opii, R. Sultana, H. Mohmmad Abdul, M. Ansari, A. Nath and D. A. Butterfield, "Oxidative Stress and Toxicity Induced by the Nucleoside Reverse Transcriptase Inhibitor (NRTI) - 2',3'-Dideoxycytidine (ddC): Relevance to HIV Dementia," Experimental Neurology, 204, 29-38 (2007). 382. D. A. Butterfield, “Amyloid b-Peptide (1-42), Oxidative Stress and Alzheimer’s Disease,” in Abeta and Alzheimer’s Disease, C.Barrow and D. Small, Eds., Springer, London, pp. 83-92 (2007). 381. R. Vaishnav, M. Getchell, H. F. Poon, K. Barnett, S. Hunter, W. Pierce, J. B. Klein, D. A. Butterfield and T. Getchell, "Oxidative Stress in the Aging Murine Olfactory Bulb: Redox Proteomics and Cellular Localization," Journal of Neuroscience Research, 85, 373-385 (2007). 380. G. Joshi, S. Hardas, R. Sultana, M. Vore, D. St. Clair and D. A. Butterfield, "Glutathione Elevation by Gamma-Glutamylcysteine Ethyl Ester as a Potential Therapeutic Strategy Towards Preventing Oxidative Stress in Brain Mediated by In Vivo Administration of Adriamycin: Implications for Chemobrain," Journal of Neuroscience Research, 85, 497-503 (2007). 379. H. Mohmmad Abdul and D. A. Butterfield, "Involvement of PI3K/PKG/ERK1/2 Signaling Pathways in Cortical Neurons to Trigger Protection by Co-treatment of Acetyl-L-Carnitine and Alpha-Lipoic Acid Against HNE-Mediated Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease," Free Radic. Biol. Med., 42, 371-384 (2007). 378. J. Tangpong, M. P. Cole, R. Sultana, S. Estus, M. Vore, W. St. Clair, S. Ratanachaiyavong, D. K. St. Clair and D. A. Butterfield, "Adriamycin Mediated Nitration of Manganese Superoxide Dismutase in the Central Nervous System: Insight into the Mechanism of Chemobrain," Journal of Neurochemistry 100, 191-201 (2007). 377. C. Mancuso, G. Scapagnini, D. Gurro, A.M. Giuffrida Stella, C. De Marco, D. A. Butterfield, and V. Calabrese. “Mitochondrial Dysfunction, Free Radical Generation and Cellular Stress Response in Neurodegenerative Disorders,” Frontiers Biosci.12, 1107-1123 (2007). 376. V. Calabrese, C. Mancuso, C. De Mello, A. M. Gifffrida Stella and D. A. Butterfield, "Nitric Oxide and Cellular Stress Response in Brain Aging and Neurodegenerative Disorders," in Oxidative Stress and Neurological Disorders, G. A. Qureshi and S. Hassan Parvez, Eds.., Elsevier Publishers, Amsterdam, 2007, pp. 115-134. 375. P. A. Crooks, S. G. Kottayil, A. M. Al-Ghananeem, S. R. Bryn and D. A. Butterfield, "Opiate Receptor Binding Properteis of Morphine-, Dihydromorphine-, and Codeine 6-O-Sulfate Ester Congeners," Bioorg. Med. Chem. Lett., 16, 4291-4295 (2006). 374. V. Calabrese, E. Guagliano, M. Sapienza, C. Mancuso, D. A. Butterfield, and A.M. Stella, “Redox Regulation of Cellular Stress Response in Neurodegenerative Disorders,” Italian J. Biochem. 55, 263-282 (2006). 373. D. A. Butterfield, A. Gnjec, H. F. Poon, A. Castegna, W. M. Pierce, J. B. Klein and R. N. Martins, "Redox Proteomics Identification of Oxidatively Modified Brain Proteins in Inherited Alzheimer's Disease: An Initial Assessment," Journal of Alzheimer's Disease, 10, 391-397 (2006). 372. V. Smuleac, D. A. Butterfield and D. Bhattacharyya, "Layer-by-Layer Assembled Microfiltration Membranes for Biomolecule Immobilization and Enzymatic Catalysis," Langmuir, 22, 10118-10124 (2006). 371. P. Jungsuwadee, M. P. Cole, R. Sultana, G. Joshi, J. Tanpong, D. A. Butterfield, D. K. St. Clair and M. Vore, "Increase in Mrp1 Expression and HNE Adduction in Heart Tissue of Adriamycin-Treated C57BL/6 Mice," Molecular Cancer Therapeutics, 5, 2851-60. (2006). 370. M. A. Ansari, G. Joshi, Q. Huang, W. O. Opii, H. Mohmmad Abdul, R. Sultana and D. A. Butterfield, "In Vivo Administration of D609 Leads to Protection of Subsequently Isolated Gerbil Brain Mitochondria Subjected to In Vitro Oxidative Stress Induced by Amyloid Beta-Peptide and Other Oxidative Stressors: Relevance to Alzheimer's Disease and Other Oxidative Stress-Related Neurodegenerative Disorders," Free Radial Biology & Medicine, 41, 1694-1703 (2006). 369. Y. Chen, C. Daosukho, W. O. Opii, D. N. Turner, W. M. Pierce, J. B. Klein, M. Vore, D. A. Butterfield and D. K. St. Clair, "Redox Proteomics Identification of Oxidized Cardiac Proteins in Adriamycin-Treated Mice," Free Radic. Biol. Med., 41, 1470-1477 (2006). 368. R. Sultana, D. Boyd-Kimball, H. F. Poon, J. Cai, W. M. Pierce, J. B. Klein, M. Merchant, W. R. Markesbery and D. A. Butterfield, "Redox Proteomics Identification of Oxidized Proteins in Alzheimer's Disease Hippocampus and Cerebellum: An Approach to Understand Pathological and Biochemical Alterations in AD," Neurobiology of Aging, 27, 1564-1576 (2006). 367. J. Steiner, N. Haughey, W. Li, A. Venkatesan, C. Anderson, R. Reid, T. Malpica1, C. Pocernich, D. A. Butterfield and A. Nath, "Oxidative Stress and Therapeutic Approaches in HIV Dementia," Antioxidants and Redox Signaling, 8, 2089-2100 (2006). 366. R. Sultana, M. Perluigi and D. A. Butterfield, "Protein Oxidation and Lipid Peroxidation in Brain of Subjects with Alzheimer’s Disease: Insights into Mechanism of Neurodegeneration from Redox Proteomics," Antioxidants and Redox Signaling, 8, 2021-2037 (2006). 365. V. Calabrese, R. Sultana, G. Scapagnini, E. Guagliano, M. Sapienza, R. Bella, J. Kanski, G. Pennisi, C. Mancuso, A. M. Giuffrida Stella and D. A. Butterfield, "Nitrosative Stress, Cellular Stress Response, and Thiol Homeostasis in Patients with Alzheimer’s Disease," Antioxidants and Redox Signaling, 8, 1975-1986 (2006). 364. D. A. Butterfield, "Oxidative Stress in Neurodegenerative Disorders," Antioxidants and Redox Signaling, 8, 1971-1974 (2006). 363. D. A. Butterfield, H. Mohmmad Abdul, W. Opii, S. F. Newman, G. Joshi, M. A., Ansari and R. Sultana, "Pin1 in Alzheimer's Disease," Journal of Neurochemistry, 98, 1697-1706 (2006). 362. D. A. Butterfield, M. Perluigi and R. Sultana, "Oxidative Stress in Alzheimer's Disease Brain: New Insights from Redox Proteomics," Eur. J. Pharmacol., 545, 39-50 (2006). 361. D. A. Butterfield and R. Sultana, "Redox Proteomics Analysis of Oxidatively Modified Brain Proteins in Alzheimer's Disease," in Proteomics of Neurodegenerative Disease, T. J. Montine, Ed., Transworld Research Network Publishers, Trivandrum, India, 2006, pp. 95-113. 360. M. Perluigi, G. Joshi, R. Sultana, V. Calabrese, C. De Marco, R. Coccia, C. Cini and D. A. Butterfield, "In Vivo Protective Effects of Ferulic Acid Ethyl Ester Against Amyloid b- Peptide (1-42)-Induced Oxidative Stress," J. Neuroscience Res., 84, 418-426 (2006). 359. R. Sultana, S. F. Newman, H. Mohmmad-Abdul, J. Cai, W. M. Pierce, J. B. Klein, M. Merchant and D. A. Butterfield, "Protective Effect of D609 Against Ab(1-42)-Induced Oxidative Modification of Neuronal Proteins: Redox Proteomics Study," J. Neuroscience Res., 84, 409-417 (2006). 358. H. Mohmmad-Abdul, V. Calabrese, M. Calvani and D. A. Butterfield, "Acetyl-L-Carnitine-Induced Up-Regulation of HSPs Protects Cortical Neurons Against Ab (1-42)-Mediated Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease," J. Neuroscience Res., 84, 398-408 (2006). 357. D. Boyd-Kimball, H. F.Poon, B. C. Lynn, J. Cai, W. M. Pierce, Jr., J. B. Klein, J.Ferguson, C. D. Link and D. A. Butterfield, "Proteomic Identification of Proteins Specifically Oxidized in Caenorhabditis elegans Expressing Human Ab(1-42): Implications for Alzheimer's Disease," Neurobiology of Aging, 27, 1239-1249 (2006). 356. D. A. Butterfield, H. Mohmmad Abdul, S. Newman and T. Reed, "Redox Proteomics in Some Age-Related Neurodegenerative Disorders or Models Thereof," NeuroRx, 3, 344-357 (2006). 355. S. J. Chinta, S. Rajagopalan, D. A. Butterfield and J. K. Andersen, "In Vitro and In Vivo Neuroprotection by (-Glutamylcysteine Ethyl Ester Against MPTP: Relevance to the Role of Glutathione in Parkinson's Disease," Neurosocience Letts., 402, 137-141 (2006). 354. J. Tangpong, M. P. Cole, R. Sultana, G. Joshi, S. Estus, M. Vore, W. St. Clair, S. Ratanachaiyavong, D. St. Clair and D. A. Butterfield, "Adriamycin-Induced, TNF- "-Mediated Central Nervous System Toxicity," Neurobiology of Disease, 23, 127-139 (2006). 353. K. A. Langer, H. F. Poon, G. Munch, B. C. Lynn, T. Arendt and D. A. Butterfield, "Identification of AGE-Modified Proteins in SH-SY5Y and OLN-93 Cells," Neurotoxicity Research, 9, 255-268 (2006).

352. H. F. Poon, H. M. Shepherd, T. T. Reed, V. Calabrese, A. M. Giuffrida-Stella, G. Pennisi, J. Cai, W. M. Pierce, J. B. Klein and D. A. Butterfield, "Proteomics Analysis Provides Insight into Caloric Restriction Mediated Oxidation and Expression of Brain Proteins Associated with Age-Related Impaired Cellular Processes: Mitochondrial Dysfunction, Glutamate Dysregulation and Impaired Protein Synthesis," Neurobiology of Aging, 27, 1020-1034 (2006).

351. H. F. Poon, R. A. Vaishnav, T. V. Getchell, M. L. Getchell and D. A. Butterfield, "Quantitative Proteomics Analysis of Differential Protein Expression and Oxidative Modification of Specific Proteins in the Brains of Old Mice," Neurobiology of Aging, 27, 1010-1019 (2006).

350. R. Sultana, D. Boyd-Kimball, H. F. Poon, J. Cai, W. M. Pierce, J. B. Klein, W. R. Markesbery, X. Z. Zhou, K. P. Lu and D. A. Butterfield, "Oxidative Modification and Down-Regulation of Pin 1 in Alzheimer's Disease Hippocampus: A Redox Proteomics Analysis," Neurobiology of Aging, 27, 918-925 (2006).

349. V. Calabrese, C. Colombrita R. Sultana, G. Scapagnini, M. Calvani and D. A. Butterfield , "Redox Modulation of Heat Shock Protein Expression by Acetylcarnitine in Aging Brain: Relationship to Antioxidant Status and Mitochondrial Function," Antioxidants and Redox Signaling , 8 , 404-416 (2006).

348. H. F. Poon, V. Calabrese, M. Calvani and D. A. Butterfield , "Proteomics Analyses of Specific Protein Oxidation and Protein Expression in Aged Rat Brain and Its Modulation by L-Acetylcarnitine: Insights into the Mechanisms of Action of this Proposed Therapeutic Agent for CNS Disorders Associated with Oxidative Stress," Antioxidants and Redox Signaling , 8 , 381-394 (2006).

347. D. A. Butterfield , H. F. Poon, D. St. Clair, J. N. Keller, W. M. Pierce, J. B. Klein and W. R. Markesbery, "Redox Proteomics Identification of Oxidatively Modified Hippocampal Proteins in Mild Cognitive Impairment: Insights into the Development of Alzheimer's Disease," Neurobiology of Disease , 22 , 223-232 (2006).

346. R. Sultana, M. Perluigi and D. A. Butterfield , "Redox Proteomics Identification of Oxidatively Modified Proteins in Alzheimer's Disease Brain and In Vivo and In Vitro Models of AD Centered Around Ab(1-42)," J. Chromatogr. B Anaylt. Technol. Biomed. Life Sci. , 833 , 3-11 (2006).

345. R. Sultana, H. F. Poon, J. Cai, W. M. Pierce, M. Merchant, J. B. Klein, W. R. Markesbery and D. A. Butterfield , "Identification of Nitrated Hippocampal Proteins in Alzheimer's Disease Brain Using a Redox Proteomics Approach," Neurobiology of Disease , 22 , 76-87 (2006).

344. V. Calabrese, D. A. Butterfield , G. Scapagnini, A. M. Giuffrida Stella and M. D. Maines."Redox Regulation of Heat Shock Protein Expression by Signaling Involving Nitric Oxide and Carbon Monoxide: Relevance to Brain Aging, Neurodegenerative Disorders, and Longevity," Antioxidants and Redox Signaling , 8 , 444-477 (2006).

343. M. Perluigi, G. Joshi, R. Sultana, V. Calabrese, C. De Marco, R. Coccia and D. A. Butterfield , " In Vivo Protection by the Xanthate D609 Against Amyloid b-Peptide (1-42)-Induced Oxidative Stress: Implications for Alzheimer's Disease," Neuroscience , 138 , 1161-1170 (2006).

342. D. A. Butterfield , T. Reed, M. Perluigi, C. De Marco, R. Coccia, C. Cini and R. Sultana, "Elevated Protein-Bound Levels of the Lipid Peroxidation Product, 4-Hydroxy-2-Nonenal, in Brain from Persons with Mild Cognitive Impairment," Neuroscience Letts. , 397 , 170-173 (2006).

341. D. Ranjan, C. Chen, T. D. Johnston, H. Jeon, M. Ibrahim, J. Drake and D. A. Butterfield , "Stimulation of Epstein-Barr Virus-Infected Human B Cell Growth by Physiological Concentrations of 4-Hydroxynonenal," Cell Biochem. Funct. , 24 , 147-152 (2006).

340. O. Bartov, R. Sultana, D. A. Butterfield and D. Atlas, "Low Molecular Weight Thiol Amides Attenuate MAPK Activity and Protect Primary Neurons from Ab(1-42) Toxicity," Brain Research , 1069 , 198-206 (2006).

339. D. A. Butterfield, R. Sultana and H. F. Poon, "Redox Proteomics: A New Approach to Investigate Oxidative Stress in Alzheimer's Disease," in Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases , (I. Dalle-Donne, A. Scaloni, and D. A. Butterfield, Eds.), Wiley Press, New York, 2006, pp. 563-603.

338. I. Dalle-Donne, A. Scaloni and D. A. Butterfield, Eds., Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases , Wiley Press, New York (2006).

337. H. Mohmmad-Abdul, R. Sultana, J. N. Keller, D. K. St. Clair, W. R. Markesbery and D. A. Butterfield, "Mutations in Amyloid Precursor Protein and Presenilin-1 Genes Increase the Basal Oxidative Stress in Murine Neuronal Cells and Lead to Increased Sensitivity to Oxidative Stress Mediated by Amyloid b-Peptide (1-42), H 2O 2 and Kainic Acid: Implications for Alzheimer’s Disease," Journal of Neurochemistry , 96 , 1322-1335 (2006).

336. G. Joshi, M. Perluigi, R. Sultana, R. Agrippino, V. Calabrese and D. A. Butterfield, " In Vivo Protection of Synaptosomes by Ferulic Acid Ethyl Ester (FAEE) from Oxidative Stress Mediated by 2,2-Azobis (2-Amidino-propoane) Dihyrochloride (AAPH) or Fe 2+/H 2O 2: Insight into Mechanisms of Neuroprotection and Relevance to Oxidative Stress Related Neurodegenerative Disorders," Neurochemistry International , 48 , 318-327 (2006).

335. V. Calabrese, M. Calvani, A. M. Giuffrida Stella and D. A. Butterfield, "Acetylcarnitine and Cellular Stress Response: Roles in Nutrition Redox Homeostasis and Regulation of Longevity Genes," J. Nutritional Biochemistry , 17 , 73-88 (2006).

334. D. A. Butterfield, H. F. Poon and R. Sultana, "Proteomic Identification of Oxidatively Modified Proteins in Alzheimer's Disease Brain and Models Thereof: Insights into Potential Mechanisms of Neurodegeneration," in Oxidative Stress and Age-Related Neurodegeneration , (Y. Luo and L. Packer, Eds.), CRC Press/Taylor and Francis Publishers, Boca Raton, FL, 2006, pp. 1-25.

333. M. Perluigi, H. F. Poon, W. Maragos, W. M. Pierce, J. B. Klein, V. Calabrese, C. Cini, C. De Marco and D. A. Butterfield, "Proteomic Analysis of Protein Expression and Oxidative Modification in R6/2 Transgenic Mice--A Model of Huntington's Disease," Molecular and Cellular Proteomics , 4 , 1849-1861 (2005).

332. G. Joshi, R. Sultana, J. Tangpong, M. P. Cole, D. K. St. Clair, M. Vore, S. Estus and D. A. Butterfield, "Free Radical Mediated Oxidative Stress and Toxic Side Effects in Brain Induced by the Anti Cancer Drug Adriamycin: Insight into Chemobrain," Free Radical Research , 39 , 1147-1154 (2005).

331. C. B. Pocernich, R. Sultana, H. Mohmmad Abdul, A. Nath and D. A. Butterfield, "HIV-Dementia, Tat-Induced Oxidative Stress and Antioxidant Therapeutic Considerations," Brain Res. Rev. , 50 , 14-26 (2005).

330. D. A. Butterfield and H. F. Poon, "The Senescence-Accelerated Prone Mouse (SAMP8): A Model of Age-Related Cognitive Decline with Relevance to Alterations of the Gene Expression and Protein Abnormalities in Alzheimer's Disease," Experimental Gernontology , 40 , 774-783 (2005).

329. V. Calabrese, C. Colombrita, E. Guagliano, M. Sapienza, A. Ravagna, V. Cardile, G. Scapagnini, A. M. Santoro, A. Mangiameli, D. A. Butterfield, A. M. Giuffrida Stella and E. Rizzarelli, "Protective Effect of Carnosine During Nitrosative Stress in Astroglial Cell Cultures," Neurochemical Research , 30 , 797-807 (2005).

328. Y. Zhu, G. Jones, S. Tsutsui, W. Opii, S. Liu, C. Silva, D. A. Butterfield and C. Power, "Lentivirus Infection Causes Neuroinflammation and Neuronal Injury in Dorsal Root Ganglia: Pathogenic Effects of STAT-1 and Inducible Nitric Oxide Synthase," J. Immunology , 175 , 1118-1126 (2005).

327. V. Calabrese, R. Lodi, C. Tonon, A. Ravagna, M. Sapienza, C. Colombrita, G. Scapagnini and D. A. Butterfield, "Oxidative Stress, Mitochondrial Dysfunction, and Cellular Stress Response in Friedreich's Ataxia," J. Neurol. Sci. , 233 , 145-162 (2005).

326. H. F. Poon, S. A. Farr, W. A. Banks, W. M. Pierce, J. B. Klein, J. E. Morley and D. A. Butterfield, "Proteomic Identification of Brain Proteins in Aged Senescence Accelerated Mice That Have Decreased Oxidative Modification Following Administration of Antisense Oligonucleiotide Directed at the Ab Region of Amyloid Precursor Protein," Molecular Brain Res. , 138 , 8-16 (2005).

325. H. F. Poon, K. Hensley, V. Thongboonkerd, M. L. Merchant, B. C. Lynn, W. M. Pierce, J. B. Klein, V. Calabrese and D. A. Butterfield, "Proteomic Analysis of Oxidatively Modified Proteins in G93A-SOD1 Transgenic Mice-A Model of Familial Amyotrophic Lateral Sclerosis," Free Radical Biology & Medicine , 39 , 453-462 (2005).

324. H. F. Poon, R. A. Vaishnav, D. A. Butterfield, M. L. Getchell and T. V. Getchell, "Proteomic Identification of Differentially Expressed Proteins in the Aging Murine Olfactory System and Transcriptional Analysis of the Associated Genes," J. Neurochemistry , 94 , 380-392 (2005).

323. H. Mohmmad Abdul and D. A. Butterfield, "Protection Against Amyloid Beta-Peptide (1-42)-Induced Loss of Phospholipid Asymmetry in Synaptosomal Membranes by Tricyclodecan-9-xanthogenate (D609) and Ferulic Acid Ethyl Ester: Implications for Alzheimer's Disease," Biochim. Biophys. Acta , 1741 , 140-148 (2005).

322. D. Boyd-Kimball, A. Castegna, R. Sultana, H. F. Poon, R. Petroze, B. C. Lynn, J. B. Klein and D. A. Butterfield, "Proteomic Identification of Proteins Oxidized by Ab(1-42) in Synaptosomes: Implications for Alzheimer's Disease," Brain Research , 1044 , 206-215 (2005).

321. V. Smuleac, D. A. Butterfield, S. K. Sikdar, R. S. Varma and D. Bhattacharyya, "Polythiol Functionalized Alumina Membranes for Mercury Capture," J. Membrane Sci. , 251 , 169-178 (2005).

320. J. N. Keller, F. A. Schmitt, S. W. Scheff, Q. Ding, Q. Chen, D. A. Butterfield and W. R. Markesbery, "Evidence of Increased Oxidative Damage in Subjects with Mild Cognitive Impairment," Neurology , 64 , 1152-1156 (2005).

319. D. Boyd-Kimball, R. Sultana, H. F. Poon, B. C. Lynn, F. Casamenti, G. Pepeu, J. B. Klien and D. A. Butterfield, "Proteomic Identification of Proteins Specifically Oxidized by Intracerebral Injection of Ab(1-42) into Rat Brain: Implications for Alzheimer's Disease," Neuroscience , 132 , 313-324 (2005).

318. G. Joshi, R. Sultana, M. Perluigi and D. A. Butterfield, " In Vivo Protection of Synaptosomes from Oxidative Stress Mediated by Fe 2+/H 2O 2 or 2,2-Azobis (2-amidinopropane) dihydrochloride (AAPH) by the Glutathione Mimetic Tricyclodecan-9-yl-xanthogenate (D609)," Free Radical Biology & Medicine , 38 , 1023-1031 (2005).

317. H. F. Poon, M. Frasier, N. Shreve, V. Calabrese, B. Wolozin and D. A. Butterfield, "Mitochondrial Associated Metabolic Proteins are Selectively Oxidized in A30P "a-Synuclein Mice - A Model of Familial Parkinson's Disease," Neurobiology of Disease , 18 , 492-498 (2005).

316. M. Perluigi, H. F. Poon, K. Hensley, W. M. Pierce, J. B. Klein, V. Calabrese, C. DeMarco and D. A. Butterfield,"Proteomic Analysis of 4-Hydroxy-2-Nonenal-Modified Proteins in G93A-SOD1 Transgenic Mice - A Model of Familial Amytrophic Lateral Sclerosis," Free Radical Biology & Medicine , 38 , 960-968 (2005).

315. D. Boyd-Kimball, R. Sultana, H. Mohmmad-Abdul and D. A. Butterfield, "Neurotoxicity and Oxidative Stress in D1M-Substituted Alzheimer’s Ab(1-42): Relevance to N-Terminal Methionine Chemistry in Small Model Peptides," Peptides , 26 , 665-673 (2005).

314. D. Boyd-Kimball, R. Sultana, H. F. Poon, H. Mohammad-Abdul, B. C. Lynn, J. B. Klein and D. A. Butterfield, " (y-Glutamylcysteine Ethyl Ester Protection from Ab(1-42)-Mediated Oxidative Stress in Neuronal Cells: A Proteomics Approach," J. Neuroscience Res. , 79 , 707-713 (2005).

313. D. Boyd-Kimball, R. Sultana, H. Mohammad-Abdul and D. A. Butterfield, " y-Glutamylcysteine Ethyl Ester Induced Upregulation of Glutathione Protects Neurons Against Ab(1-42)-Mediated Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease," J. Neuroscience Res. , 79 , 700-706 (2005).

312. C. B. Pocernich, D. Boyd-Kimball, H. F. Poon, V. Thongboonkerd, B. C. Lynn, J. B. Klein, V. Calabrese, A. Nath and D. A. Butterfield, "Proteomics Analysis of Human Astrocytes Expressing the HIV Protein Tat," Molec. Brain Res. , 133 , 307-316 (2005).

311. C. B. Pocernich, H. F. Poon, D. Boyd-Kimball, B. C. Lynn, A. Nath, J. B. Klein and D. A. Butterfield, "Proteomics Analysis of Oxidatively Modifed Proteins Induced by the Mitochondrial Toxin 3-Nitropropionic Acid in Human Astrocytes Expressing the HIV Protein Tat," Molec. Brain Res. , 133 , 299-306 (2005).

310. V. Calabrese, A. Ravagna, C. Colombrita, E. Guagliano, G. Tomaselli, A. M. Giuffrida Stella, M. Calvani and D. A. Butterfield, "Acetylcarnitine Induces Heme Oxygenase in Rat Astrocytes and Protects Against Oxidative Stress: Involvement of the Transcription Factor Nrf2," J. Neurosci. Res. , 79 , 509-521 (2005).

309. R. Sultana, A. Ravagna, H. Mohmmad-Abdul, V. Calabrese and D. A. Butterfield, "Ferulic Acid Ethyl Ester Protects Neurons Against Amyloid b-Peptide (1-42)-Induced Oxidative Stress and Neurotoxicity: Relationship to Antioxidant Activity," J. Neurochemistry , 92 , 749-758 (2005).

308. D. A. Butterfield and D. Boyd-Kimball, "The Critical Role of Methionine 35 in Alzheimer's Amyloid b-Peptide (1-42)-Induced Oxidative Stress and Neurotoxicity," Biochimica et Biophysica Acta , 1703 , 149-156 (2005).

307. H. F. Poon, S. A. Farr, V. Thongboonkerd, B. C. Lynn, W. A. Banks, J. E. Morley, J. B. Klein and D. A. Butterfield, "Proteomic Analysis of Specific Brain Proteins in Aged SAMP8 Mice Treated with alpha-Lipoic Acid: Implications for Aging and Age-Related Neurodegenerative Disorders," Neurochemistry International , 46 , 159-168 (2005).

306.   D. Boyd-Kimball, H. Mohmmad Abdul, T. Reed, R. Sultana and D. A. Butterfield, "Role of Phenylalanine 20 in Alzheimer's Amyloid b-Peptide (1-42)-Induced Oxidative Stress and Neurotoxicity," Chem. Res. Toxicol. , 17 , 1743-1749 (2004).

305.   R. Sultana and D. A. Butterfield, "Oxidatively Modified GST and MRP1 in Alzheimer's Disease Brain: Implications for Accumulation of Reactive Lipid Peroxidation Products," Neurochemical Research , 29 , 2215-2220 (2004).

304.   V. Calabrese, M. Calvani and D. A. Butterfield, "Increased Formation of Short-Chain Organic Acids After Chronic Ethanol Administration and Its Interaction With the Carnitine Pool in Rat," Archives of Biochemistry and Biophysics , 431 , 271-278 (2004).

303.   M. Brito, D. Brites and D. A. Butterfield, "A Link Between Hyperbilirubinemia, Oxidative Stress, and Injury to Neocortical Synaptosomes," Brain Research , 1026 , 33-43 (2004).

302.   D. Boyd-Kimball, R. Sultana, H. Mohmmad-Abdul and D. A. Butterfield, "Rodent Ab(1-42) Exhibits Oxidative Stress Properties Similar to Those of Human Ab(1-42): Implications for Proposed Mechanisms of Toxicity," Journal of Alzheimer's Disease , 6 , 515-525 (2004).

301.   D. A. Butterfield and D. Boyd-Kimball, "Proteomics Analysis in Alzheimer's Disease: New Insights Into Mechanisms of Neurodegeneration," International Rev. Neurobiol. , 61 , 159-188 (2004).

300.   D. A. Butterfield and D. Boyd-Kimball, "Amyloid b-Peptide(1-42) Contributes to the Oxidative Stress and Neurodegeneration Found in Alzheimer's Disease Brain," Brain Pathology , 14 , 426-432 (2004).

299.   H. Mohmmad Abdul, G. L. Wenk, M. Gramling, B. Hauss-Wegrzyniak and D. A. Butterfield, "APP and PS-1 Mutations Induce Brain Oxidative Stress Independent of Dietary Cholesterol: Implications for Alzheimer's Disease," Neurosci. Lett. , 368 , 148-150 (2004).

298.   J. M. Antony, G. van Marle, W. Opii, D. A. Butterfield, F. Mallet, V. W. Yong, J. L. Wallace, R. M. Deacon, K. Warren and C. Power, "Human Endogenous Retrovirus Glycoprotein-Mediated Induction of Redox Reactants Causes Oligodendrocyte Death and Demyelination," Nature Neuroscience , 7 , 1088-1095 (2004).

297.   V. Smuleac, D. A. Butterfield and D. Bhattacharyya, "Permeability and Separation Characteristics of Polypeptide Functionalized Polycarbonate Track-Etched Membranes," Chemistry of Materials , 16 , 2762-2771 (2004).

296.   V. Calabrese, A. M. Giuffrida Stella, D. A. Butterfield and G. Scapagnini, "Redox Regulation in Neurodegeneration and Longevity: Role of Heme Oxgenase and HSP70 Systems in Brain Stress Tolerance," Antioxidants and Redox Signaling , 6 , 895-913 (2004).

295.   H. F Poon, G. Joshi, R. Sultana, S. A. Farr, W. A. Banks, J. E. Morley, V. Calabrese and D. A. Butterfield, "Antisense Directed at the A b Region of APP Decreases Brain Oxidative Markers in Aged Senescence Accelerated Mice," Brain Research , 1018 , 86-96 (2004).

294.   C. B. Pocernich, R. Sultana, E. Hone, J. Turchan, R. N. Martins, V. Calabrese, A. Nath and D. A. Butterfield, "Effects of Apolipoprotein E on the Human Immunodeficiency Virus Protein Tat in Neuronal Cultures and Synaptosomes," J. Neurosci. Res. , 77 , 532-539 (2004).

293.   V. Calabrese, D. Boyd-Kimball, G. Scapagnini and D. A. Butterfield, "Nitric Oxide and Cellular Stress Response in Brain Aging and Neurodegenerative Disorders: The Role of Vitagenes," In Vivo , 18 , 245-268 (2004).

292.   G. Scapagnini, D. A. Butterfield, C. Colombrita, R. Sultana, A. Pascale and V. Calabrese, "Ethyl Ferulate, a Lipophilic Polyphenol, Induces HO-1 and Protects Rat Neurons Against Oxidative Stress," Antioxidants and Redox Signaling , 6 , 811-818 (2004).

291.   H. F. Poon, A. Castegna, S. A. Farr, V. Thongboonkerd, B. C. Lynn, W. A. Banks, J. E. Morley, J. B. Klein and D. A. Butterfield, "Quantitative Proteomics Analysis of Specific Protein Expression and Oxidative Modification in Aged SAMP8 Mouse Brain," Neuroscience , 126 , 915-926 (2004).

290.   H. F. Poon, V. Calabrese, G. Scapagnini and D. A. Butterfield, "Free Radicals in Brain Aging," Clinics in Geriatric Medicine , 20 , 329-359 (2004).

289.   D. A. Butterfield and A. I. Bush, "Alzheimer's Amyloid b-Peptide (1-42): Involvement of Methionine Residue 35 in the Oxidative Stress and Neurotoxicity Properties of This Peptide," Neurobiology of Aging , 25 , 563-568 (2004).

288.   D. A. Butterfield, "Oxidative Stress in Animal Models of Accelerated Aging, Alzheimer's Disease and Huntington's Disease," in Frontiers of Medicinal Chemistry , (A. B. Reitz, C. P. Kordki, M. I. Choudhary and A. U. Rahman, Eds.), Bentham Science Publishers, New York, 2004, pp. 385-397.

287.   R. Sultana, S. Newman, H. Mohmmad-Abdul, J. N. Keller and D. A. Butterfield, "Protective Effect of the Xanthate, D609, on Alzheimer's Amyloid b-Peptide (1-42)-Induced Oxidative Stress in Primary Neuronal Cells," Free Radical Research , 38 , 449-458 (2004).

286.   H. F. Poon, V. Calabrese, G. Scapagnini and D. A. Butterfield, "Free Radicals: Key to Brain Aging and Heme Oxygenase as a Cellular Response to Oxidative Stress," J. Gerontology , 59 , 478-493 (2004).

285.   B. Downie, L. M. A. Dirk, Q. Xu, J. Drake, D. Zhang, M. Dutt, A. Levy, D. A. Butterfield, R. R. Geneve, J. W. Corum, III, K.G. Lindstrom and J. C. Snyder, "A Physical, Enzymatic, and Genetic Characterization of Perturbations in the Seeds of the Brownseed Tomato Mutants," J. Exp. Bot. , 55 , 961-973 (2004).

284.   W. F. Maragos, K. L. Young, C. S. Altman, C. B. Pocernich, J. Drake, D. A. Butterfield, I. Seif, D. P. Holschneider, K. Chen and J. C. Shih, "Striatal Damage and Oxidative Stress Induced by the Mitochondrial Toxin Malonate are Reduced in Clorgyline-Treated Rats and MAO-A Deficient Mice," Neurochemical Res. , 29 , 741-746 (2004).

283.   D. A. Butterfield, "Insights into Mechanisms of Neurodegeneration," Innovation , 4 , 46-47 (2004).

282.   V. Calabrese, G. Scapagnini, A. Ravagna, C. Colombrita, F. Spadaro, D. A. Butterfield and A. M. Giuffrida-Stella, "Increased Expression of Heat Shock Proteins in Rat Brain During Aging: Relationship with Mitochondrial Function and Glutathione Redox State," Mech. Ageing Develop. , 125 , 325-335 (2004).

281.   A. Castegna, C. M. Lauderback, H. Mohmmad-Abdul and D. A. Butterfield, "Modulation of Phospholipid Asymmetry in Synaptosomal Membranes by the Lipid Peroxidation Products, 4-Hydroxynonenal (HNE) and Acrolein: Implications for Alzheimer's Disease," Brain Research , 1004 , 193-197 (2004).

280.   D. A. Butterfield, "Proteomics: A New Approach to Investigate Oxidative Stress in Alzheimer's Disease Brain," Brain Research , 1000 , 1-7 (2004).

279.   J. Drake, R. Petroze, A. Castegna, Q. Ding, J. N. Keller, W. R. Markesbery, M. A. Lovell and D. A. Butterfield, "4-Hydroxynonenal Oxidatively Modifies Histones: Implications for Alzheimer's Disease," Neuroscience Lett. , 356 , 155-158 (2004).

278.   A. Castegna, V. Thongboonkerd, J. Klein, B. C. Lynn, Y. L. Wang, H. Osaka, K. Wada and D. A. Butterfield, "Proteomic Analysis of Brain Proteins in the Gracile Axonaly Dystrophy (gad) Mouse, a Syndrome that Emanates from Dysfunctional Uquiquitin Carboxyl-Terminal Hydrolase L-1, Reveals Oxidation of Key Proteins," Journal of Neurochemistry , 88 , 1540-1546 (2004).

277.   D. A. Butterfield, "The Glutamatergic System in Alzheimer's Disease Brain: Dysfunction Associated with Amyloid b-Peptide and Oxidative Stress," in Excitotoxicity in Neurological Diseases , C. Ferrarese and M. F. Beal, Eds., Kluwer Academic Publishes, Boston, 2004, pp. 251-262.

276.   V. Calabrese, D. A. Butterfield and A. M. Giuffrida-Stella, "Nutritional Antioxidants and the Heme Oxygenase Pathway of Stress Tolerance: Novel Targets for Neuroprotection in Alzheimer's Disease," Italian J. Biochem. , 52 , 177-181 (2003).

275.   V. Calabrese, G. Scapagnini, C. Colombrita, A. Ravagna, G. Pennisi, A. M. Giuffrida-Stella, F. Galli and D. A. Butterfield, "Redox Regulation of Heat Shock Protein Expression in Aging and Neurodegenerative Disorders Associated with Oxidative Stress: A Nutritional Approach," Amino Acids , 25 , 437-444 (2003).

274.   J. Drake, R. Sultana, M. Aksenova, V. Calabrese and D. A. Butterfield, "Elevation of Mitochondrial Glutathione by ( y-Glutamylcysteine Ethyl Ester Protects Mitochondria Against Peroxynitrite-Induced Oxidative Stress," J. Neuroscience Res. , 74 , 917-927 (2003).

273.   D. A. Butterfield and A. Castegna, "Proteomics for the Identification of Specifically Oxidized Proteins in Brain: Technology and Application to the Study of Neurodegenerative Disorders," Amino Acids , 25 , 419-425 (2003).

272.   V. Calabrese, G. Scapagnini, A. Ravagna, R. Bella, A. M. Giuffrida Stella, M. Calvani, D. A. Butterfield and G. Pennisi, "Disruption of Thiol Homeostasis and Nitrosative Stress in the Cerebrospinal Fluid of Patients with Active Multiple Sclerosis: Evidence for a Protective Role of Acetylcarnitine," Neurochemical Research , 28 , 1321-1328 (2003).

271.   A. B. Downie, D. Zhang, L. M. A. Dirk, R. R. Thacker, J. A. Pfeiffer, J. L. Drake, A. A. Levy, D. A. Butterfield, J. W. Buxton and J. C. Snyder, "Communication Between the Maternal Testa and the Embryo and/or Endosperm Affect Testa Attributes in Tomato," Plant Physiology , 133 , 145-160 (2003).

270.   D. A. Butterfield and A. Castegna, "Proteomic Analysis of Oxidatively Modified Proteins in Alzheimer's Disease Brain: Insights into Neurodegeneration," Cellular and Molecular Biology , 49 , 747-751 (2003).

269.   J. Kanski, R. Sultana, W. Klunk and D. A. Butterfield, "Antioxidant Activity of X-34 in Synaptosomal and Neuronal Systems," Brain Research , 988 , 173-179 (2003).

268.   D. A. Butterfield and A. Castegna, "Energy Metabolism in Alzheimer's Disease Brain: Insights from Proteomics," Applied Genomics and Proteomics , 2 , 67-70 (2003).

267.   D. A. Butterfield, D. Boyd-Kimball and A. Castegna, "Proteomics in Alzheimer's Disease: Insights into Mechanisms of Neurodegeneration," J. Neurochemistry , 86 , 1313-1327 (2003).

266.   D. A. Butterfield, "Amyloid b-Peptide [1-42]-Associated Free Radical-Induced Oxidative Stress and Neurodegeneration in Alzheimer's Disease Brain: Mechanisms and Consequences," Curr. Med. Chem. , 10 , 2651-2659 (2003).

265.   D. A. Butterfield and D. Bhattacharyya, "Biofunctional Membranes: Site-Specifically Immobilized Enzyme Arrays," In: New Insights Into Membrane Science and Technology: Polymeric and Biofunctional Membranes , D. Bhattacharyya and D. A. Butterfield, Eds., Elsevier, Amsterdam, 2003, pp. 233-240.

264.   D. Bhattacharyya and D. A. Butterfield, "New Insights Into Membrane Science and Technology: Polymeric and Biofunctional Membranes," Elsevier, Amsterdam, 2003.

263.   Q. Ding, K. Reinacker, E. Dimayuga, V. Nukala, J. Drake, D. A. Butterfield, J. C. Dunn, S. Martin, A. J. Bruce-Keller and J. N. Keller, "Role of the Proteasome in Protein Oxidation and Neural Viability Following Low-Level Oxidative Stress," FEBS Letters , 546 , 228-232 (2003).

262.   D. A. Butterfield and C. B. Pocernich, "The Glutamatergic System and Alzheimer's Disease: Therapeutic Implications," CNS Drugs , 17 , 641-652 (2003).

261.   A. Castegna, V. Thongboonkerd, J. B. Klein, B. Lynn, W. R. Markesbery and D. A. Butterfield, "Proteomic Identification of Nitrated Proteins in Alzheimer's Disease Brain," J. Neurochemistry , 85 , 1394-1401 (2003).

260.   C. B. Pocernich and D. A. Butterfield, "Acrolein Inhibits NADH-Linked Mitochondrial Enzyme Activity: Implications for Alzheimer's Disease," Neurotoxicity Research , 5 , 515-520 (2003).

259.   A. Chauhan, J. Turchan, C. Pocernich, A. Bruce-Keller, S. Roth, D. A. Butterfield, E. O. Major and A. Nath, "Intracellular Human Immunodeficiency Virus Tat Expression in Astrocytes Promotes Astrocyte Survival But Induces Potent Neurotoxicity at Distant Sites via Axonal Transport," J. Biol. Chem. , 278 , 13512-13519 (2003).

258.   S. A. Farr, H. F. Poon, D. Dogrukol-Ak, J. Drake, W. A. Banks, E. Eyerman, D. A. Butterfield and J. E. Moreley, "The Antioxidants" a-Lipoic Acid and N-Acetylcysteine Reverse Memory Impairment and Brain Oxidative Stress in Aged SAMP8 Mice," Journal of Neurochemistry , 84 , 1173-1183 (2003).

257.   J. Drake, C. D. Link and D. A. Butterfield, "Oxidative Stress Precedes Fibrillar Deposition of Alzheimer's Disease Amyloid b-Peptide (1-42) in a Transgenic Caenorhabditis Elegans Model," Neurobiology of Aging , 24 , 415-420 (2003).

256.   C. M. Lauderback, J. Drake, D. Zhou, J. M. Hackett, A. Castegna, J. Kanski, M. Tsoras, S. Varadarajan and D. A. Butterfield, "Derivatives of Xanthic Acid are Novel Antioxidants: Application to Synaptosomes," Free Radical Res. , 37 , 355-365 (2003).

255.   J. Turchan, C. B. Pocernich, C. Gairola, A. Chauhan, G. Schifitto, D. A. Butterfield, S. Buch, O. Narayan, A. Sinai, J. Geiger, J. R. Berger, H. Elford and A. Nath, "Oxidative Stress in HIV Demented Patients and Protection Ex-Vivo with Novel Antioxidants," Neurology , 60 , 307-314 (2003).

254.   D. A. Butterfield, "Alzheimer's Disease: Free Radicals Run Amok," Drug Discovery & Development , 6 , 12 (2003).

253.   A. Castegna, J. Drake, C. Pocernich and D. A. Butterfield, "Protein Carbonyl Levels, an Assessment of Protein Oxidation," Apoptosis Methods in Pharmacology and Toxicology: Methods in Biological and Oxidative Stress , K. Hensley and R. A. Floyd, Eds., Human Press, Totowa, NJ, 2003, pp. 161-168.

252.   D. A. Butterfield, "Electron Paramagnetic Resonance Spin Labeling Analysis of Synaptosomal Membrane Protein Oxidation," Apoptosis Methods in Pharmacology and Toxicology: Methods in Biological and Oxidative Stress , K. Hensley and R. A. Floyd, Eds., Human Press, Totowa, NJ, 2003, pp. 79-86.

251.   V. Calabrese, G. Scapagnini, S. Latteri, C. Colombrita, A. Ravagna, C. Catalano, G. Pennisi, M. Calvani and D. A. Butterfield, "Long-Term Ethanol Administration Enhances Age-Dependent Modulation of Redox State in Different Brain Regions in the Rat: Protection by Acetyl Carnitine," Int. J. Tissue React. , 24 , 97-104 (2002).

250.   V. Calabrese, G. Scapagnini, S. Jong, D. A. Butterfield and U. Scapagnini, "Heme Oxygenase, Carbon Monoxide and Cellular Stress Response in the Nervous System: The Good and the Enigmatic," Neurochemistry News , 2 , 57-60 (2002).

249.   D. A. Butterfield, "Amyloid b-Peptide (1-42)-Induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review," Free Radical Res. , 36 , 1307-1313 (2002).

248.   D. A. Butterfield, C. B. Pocernich and J. Drake, "Elevated Gutathione as a Therapeutic Strategy in Alzheimer's Disease," Drug Development Research , 56 , 428-437 (2002).

247.   D. A. Butterfield, J. Colvin, J. Liu, J. Wang, L. Bachas and D. Bhattacharyya, "Electron Paramagnetic Resonance Spin Label Titration: A Novel Method to Investigate Random and Site-Specific Immobilization of Enzymes onto Polymeric Membranes with Different Properties," Analytica Chimica Acta , 470 , 29-36 (2002).

246.   D. A. Butterfield, A. Castegna, C. M. Lauderback and J. Drake,"Review: Evidence that Amyloid Beta-Peptide-Induced Lipid Peroxidation and Its Sequelae in Alzheimer's Disease Brain Contributes to Neuronal Death," Neurobiology of Aging , 23 , 655-664 (2002).

245.   D. A. Butterfield, S. Griffin, G. Munch and G. M. Pasinetti, "Amyloid b-Peptide and Amyloid Pathology are Central to the Oxidative Stress and Inflammatory Cascades Under Which Alzheimer's Disease Brain Exists," J. Alzheimer's Disease , 4 , 193-201 (2002).

244.   A. Castegna, M. Aksenov, M. Aksenova, V. Thongboonkerd, J. B. Klein, W. M. Pierce, R. Booze, W. R. Markesbery and D. A. Butterfield, "Proteomic Identification of Oxidatively Modified Proteins in Alzheimer's Disease Brain. Part II: Dihydropyrimidinase-Related Protein 2, " -Enolase, and Heat Shock Cognate 71," J. Neurochemistry , 82 , 1524-1532 (2002).

243.   D. A. Butterfield, A. Castegna, C. B. Pocernich, J. Drake, G. Scapagnini and V. Calabrese, "Nutritional Approaches to Combat Oxidative Stress in Alzheimer's Disease," J. Nutritional Biochemistry , 13 , 444-461 (2002).

242.   D. A. Butterfield and J. Kanski, "Review: Methionine Residue 35 is Critical for the Oxidative Stress and Neurotoxic Properties of Alzheimer's Amyloid b-Peptide 1-42," Peptides , 23 , 1299-1309 (2002).

241.   A. Castegna, M. Aksenov, M. Aksenova, V. Thongboonkerd, J. B. Klein, W. M. Pierce, R. Booze, W. R. Markesbery and D. A. Butterfield, "Proteomic Identification of Oxidatively Modified Proteins in Alzheimer's Disease Brain. Part I: Creatine Kinase BB, Glutamine Synthase, and Ubiquitin Carboxy-Terminal Hydrolase L-1," Free Radical Biol. & Med. , 33 , 562-571 (2002).

240.   V. Calabrese, G. Scapagnini, A. Ravagna, A. M. Giuffrida Stella and D. A. Butterfield, "Molecular Chaperones and Their Roles in Neural Cell Differentiation," Developmental Neuroscience , 24 , 1-13 (2002).

239.   D. A. Butterfield, A. Castegna, J. Drake, G. Scapagnini and V. Calabrese, "Vitamin E and Neurodegenerative Disorders Associated with Oxidative Stress," Nutritional Neuroscience , 5 , 229-239 (2002).

238.   J. Drake, J. Kanski, S. Varadarajan, M. Tsoras and D. A. Butterfield, "Elevation of Brain Glutathione by ( y-Glutamylcysteine Ethyl Ester Protects Against Peroxynitrite-Induced Oxidative Stress," J. Neuroscience Res. , 68 , 776-784 (2002).

237.   M. A. LaFontaine, J. W. Geddes and D. A. Butterfield, "3-Nitropropionic Acid-Induced Changes in Bilayer Fluidity in Synaptosomal Membranes: Implications for Huntington's Disease," Neurochemical Research , 27 , 507-511 (2002).

236.   J. Kanski, M. Aksenova and D. A. Butterfield, "The Hydrophobic Environment of Met35 of Alzheimer's Ab(1-42) is Important for the Neurotoxic and Oxidative Properties of the Peptide," Neurotoxicity Research , 4 , 219-223 (2002).

235.   J. Kanski, M. Aksenova, A. Stoyanova and D. A. Butterfield, "Ferulic Acid Antioxidant Protection Against Hydroxyl and Peroxyl Radical Oxidation in Synaptosomal and Neuronal Cell Culture Systems In Vitro : Structure-Activity Studies," J. Nutritional Biochem. , 13 , 273-281 (2002).

234.   J. Kanski, M. Aksenova, C. Schoneich and D. A. Butterfield, "Substitution of Isoleucine-31 by Helical-Breaking Proline Abolishes Oxidative Stress and Neurotoxic Properties of Alzheimer's Amyloid b-Peptide (1-42)," Free Radical Biol. & Med. , 32 , 1205-1211 (2002).

233.   D. A. Butterfield and C. M. Lauderback, "Lipid Peroxidation and Protein Oxidation in Alzheimer's Disease Brain: Potential Causes and Consequences Involving Amyloid b-Peptide-Associated Free Radical Oxidative Stress," Free Radical Biol. & Med. , 32 , 1050-1060 (2002).

232.   M. Aksenova, D. A. Butterfield, S. Zhang, M. Underwood and J. W. Geddes, "Increased Protein Oxidation and Decreased Creatine Kinase BB Expression and Activity Following Spinal Cord Contusion Injury," J. Neurotrauma , 19 , 491-502 (2002).

231.   J. Kanski, S. Varadarajan, M. Aksenova and D. A. Butterfield, "Role of Glycine-33 and Methionine-35 in Alzheimer's Amyloid b-Peptide 1-42-Associated Oxidative Stress and Neurotoxicity," Biochim. Biophys. Acta , 1586 , 190-198 (2002).

230.   M. A. LaFontaine, M. P. Mattson and D. A. Butterfield, "Oxidative Stress in Synaptosomal Proteins from Mutant Presenilin-1 Knock-In Mice: Implications for Familial Alzheimer's Disease," Neurochemical Research , 27 , 417-421 (2002).

229.   C. M. Lauderback, J. Kanski, J. M. Hackett, N. Maeda, M. S. Kindy and D. A. Butterfield, "Apolipoprotein E Modulates Alzheimer's Ab(1-42)-Induced Oxidative Damage to Synaptosomes in an Allele-Specific Manner," Brain Research , 924 , 90-97 (2002).

228.   D. A. Butterfield, J. Drake, C. Pocernich and A. Castegna, "Evidence of Oxidative Damage in Alzheimer's Disease Brain: Central Role of Amyloid b-Peptide," Trends Molecular Med. , 7 , 548-554 (2001).

227.   J. Kanski, J. Drake, M. Aksenova, L. Engman and D. A. Butterfield, "Antioxidant Activity of the Organotellurium Compound 3-[4-( N , N -Dimethylamino)benzenetellurenyl]-propanesulfonic Acid Against Oxidative Stress in Synaptosomal Membrane Systems and Neuronal Cultures," Brain Research , 911 , 12-21 (2001).

226.   C. B. Pocernich, A. L. Cardin, C. L. Racine, C. M. Lauderback and D. A. Butterfield, "Glutathione Elevation and Its Protective Role in Acrolein-Induced Protein Damage in Synaptosomal Membranes: Relevance to Brain Lipid Peroxidation in Neurodegenerative Disease," Neurochem. International , 39 , 141-149 (2001).

225.   D. Zhou, C. M. Lauderback, T. Yu, S. A. Brown, D. A. Butterfield and J. S. Thompson, "D609 Inhibits Ionizing Radiation-Induced Oxidative Damage by Acting as a Potent Antioxidant," J. Pharmacol. Exp. Therapeutics , 298 , 103-109 (2001).

224.   C. M. Lauderback, J. M. Hackett, F. F. Huang, J. N. Keller, L. I. Szweda, W. R. Markesbery and D. A. Butterfield, "The Glial Glutamate Transporter, GLT-1, is Oxidatively Modified by 4-Hydroxy-2-Nonenal in the Alzheimer's Disease Brain: Role of Ab 1-42," J. Neurochemistry , 78 , 413-416 (2001).

223.   S. Varadarajan, J. Kanski, M. Aksenova, C. Lauderback and D. A. Butterfield, "Different Mechanisms of Oxidative Stress and Neurotoxicity for Alzheimer's Ab(1-42) and Ab(25-35)," J. Am. Chem. Soc. , 123 , 5625-5631 (2001).

222.   D. A. Butterfield, B. J. Howard and M. A. La Fontaine, "Brain Oxidative Stress in Animal Models of Accelerated Aging and the Age-Related Neurodegenerative Disorders, Alzheimer's Disease and Huntington's Disease," Current Medicinal Chemistry , 8 , 815-828 (2001).

221.   D. A. Butterfield and J. Kanski, "Brain Protein Oxidation in Age-Related Neurodegenerative Disorders that are Associated with Aggregated Proteins," Mech. Ageing Develop. , 122 , 945-962 (2001).

220.   M. Y. Aksenov, M. V. Aksenova, D. A. Butterfield, J. W. Geddes and W. R. Markesbery, "Protein Oxidation in the Alzheimer's Disease Brain: Analysis of Protein Carbonyls by Immunocytochemistry and Two-Dimensional Western Blotting," Neuroscience , 103 , 373-383 (2001).

219.   C. M. Lauderback, J. M. Hackett, J. N. Keller, S. Varadarajan, L. Sweda, M. Kindy, W. R. Markesbery and D. A. Butterfield, "Vulnerability of Synaptosomes from Apoe Knock-Out Mice to Structural and Oxidative Modifications Induced by Ab(1-40): Implications for Alzheimer's Disease," Biochemistry , 40 , 2548-2554 (2001).

218.   S. M. Yatin, M. Yatin, S. Varadarajan, K. B. Ain and D. A. Butterfield, "Role of Spermine and Amyloid b-Peptide (1-42) Associated Free Radical Induced Neurotoxicity," J. Neurosci. Res. , 63 , 395-401 (2001).

217.   J. Kanski, C. Lauderback and D. A. Butterfield, "5-Aminosalicylic Acid Protection Against Oxidative Damage to Synaptosomal Membranes by Alkoxyl Radicals in vitro ," Neurochem. Res. , 26 , 23-29 (2001).

216.   D. A. Butterfield, D. Bhattacharyya, S. Daunert and L. G. Bachas, "Catalytic Biofunctional Membranes Containing Site-Specifically Immobilized Enzyme Arrays," J. Membrane Sci. , 181 , 29-37 (2001).

215.   G. T. Wondrak, S. Varadarajan, D. A. Butterfield and M. K. Jacobson, "Formation of a Protein-Bound Pyrazinium Free Radical Cation During Glycation of Histone H1," Free Radical Biology & Medicine , 29 , 557-567 (2000).

214.   M. A. La Fontaine, J. W. Geddes, A. Banks and D. A. Butterfield, "Effect of Exogenous and Endogenous Antioxidants on 3-Nitropropionic Acid-Induced In-Vivo Oxidative Stress and Striatal Lesions: Insights into Huntington's Disease," J. Neurochem. , 75 , 1709-1715 (2000).

213.   W. F. Maragos, R. Jakel, D. Chesnut, C. B. Pocernich, D. A. Butterfield, D. St. Clair and W. A. Cass, "Methamphetamine Toxicity is Attenuated in Mice that Overexpress Human Manganese Superoxide Dismutase," Brain Res. , 878 , 218-222 (2000).

212.   G. Liu, Y. L. Xiong and D. A. Butterfield, "Chemical, Physical, and Gel-Forming Properties of Oxidized Myofibrillar, Whey, and Soy Protein Isolates," J. Food Sci. , 65 , 811-818 (2000).

211.   S. Varadarajan, S. Yatin, M. Aksenova and D. A. Butterfield, "Review: Alzheimer's Amyloid b-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity," J. Struct. Biol. , 130 , 184-208 (2000).

210.   S. M. Yatin, S. Varadarajan and D. A. Butterfield, "Vitamin E Prevents Alzheimer's Amyloid b-Peptide (1-42)-Induced Protein Oxidation and Reactive Oxygen Species Formation," Journal of Alzheimer's Disease , 2 , 123-131 (2000).

209.   C. M. Lauderback, A. M. Breier, J. Hackett, S. Varadarajan, J. Goodlett-Mercer and D. A. Butterfield, "The Pyrrolopyrimidine U101033E is a Potent Free Radical Scavenger and Prevents Fe(II)-Induced Lipid Peroxidation in Synaptosomal Membranes," Biochim. Biophys. Acta , 1501 , 149-161 (2000).

208.   Z.-H. Guo, A. Ersoz, D. A. Butterfield and M. P. Mattson, "Beneficial Effects of Dietary Restriction on Cerebral Cortical Synaptic Terminals: Preservation of Glucose Transport and Mitochondrial Function Following Oxidative and Metabolic Insults," J. Neurochemistry , 75 , 314-320 (2000).

207.   M. Aksenov, M. Aksenova, D. A. Butterfield and W. R. Markesbery, "Oxidative Modification of Creatine Kinase BB in Alzheimer's Disease Brain," J. Neurochemistry , 74 , 2520-2527 (2000).

206.   J. N. Keller, C. M. Lauderback, D. A. Butterfield , M. S. Kindy and W. R. Markesbery, "Amyloid b-Peptide Effects on Synaptosomes from Apolipoprotein E-Deficient Mice," J. Neurochem. , 74 , 1579-1586 (2000).

205.   S. Varadarajan, S. Yatin and D. A. Butterfield , "Alzheimer's Amyloid b Peptide (1-42) Fibrils Are Not Always Toxic," Alzheimer's Reports , 3 , 71-76 (2000).

204.   D. A. Butterfield, "Alzheimer’s Amyloid b-Peptide-Associated Oxidative Stress: Brain Membrane Lipid Peroxidation and Protein Oxidation," in Membrane Structure in Disease and Drug Therapy , G. Zimmer, Ed., Marcel Dekker, New York, 2000, pp. 335-352.

203.   M. A. La Fontaine, J. W. Geddes, A. Banks and D. A. Butterfield, "3-Nitropropionic Acid Induced In-Vivo Protein Oxidation in Striatal and Cortical Synaptosomes: Insights into Huntington's Disease," Brain Research , 858 , 356-362 (2000).

202.   C. B. Pocernich, M. La Fontaine and D. A. Butterfield, " In-Vivo Glutathione Elevation Protects Against Hydroxyl Free Radical-Induced Protein Oxidation in Rat Brain," Neurochem. Int. , 36 , 185-191 (2000).

201.   D. A. Butterfield, S. M. Yatin and C. D. Link, " In-Vitro and In-Vivo Protein Oxidation Induced by Alzheimer's Disease Amyloid b-Peptide (1-42)," Ann.N.Y. Acad. Sci. , 893 , 265-268 (1999).

200.   D. A. Butterfield, S. Varadarajan, M. Aksenova, C. Link and S. M. Yatin, "On Methionine and Alzheimer's Amyloid b-Peptide (1-42)-Induced Oxidative Stress," Neurobiology of Aging , 20 , 339-342 (1999).

199.   S. M. Yatin, C. D. Link and D. A. Butterfield, " In-Vitro and In-Vivo Oxidative Stress Associated with Alzheimer’s Amyloid b-Peptide (1-42)," Neurobiology of Aging , 20 , 325-330 (1999).

198.   S. P. Gabbita, J. M. Carney and D. A. Butterfield, "Effects of Brain Mitochondrial Metabolism, Aging, and Caloric Restriction on Membrane Lipids and Proteins," in Mitochondrial Inhibitors and Neurodegenerative Disorders , P. R. Sanberg, H. Nishino and C. V. Borlongan, Eds., Humana Press Inc., Totowa, NJ, 1999, pp. 177-200.

197.   S. Varadarajan, S. Yatin, J. Kanski, F. Jahanshaki and D. A. Butterfield, "Methionine Residue 35 Is Important In Amyloid b-Peptide-Associated Free Radical Oxidative Stress," Brain Research Bulletin , 50 , 133-141 (1999).

196.   M. Aksenova, M. Y. Aksenov, W. R. Markesbery and D. A. Butterfield, "Aging in a Dish: Age-Dependent Changes of Neuronal Surrival, Protein Oxidation, and Creatine Kinase BB Expression in Long-Term Hippocampal Cell Culture," J. Neurosci. Res. , 58 , 308-317 (1999).

195.   D. A. Butterfield, "Amyloid b-Peptide-Associated Free Radical Oxidative Stress and Alzheimer's Disease," in Alzheimer's Disease and Related Disorders , K. Iqbal, D. F. Swaab, B. Winblad and H. M. Wisniewski, Eds., John Wiley & Sons, New York, 1999, pp. 405-410.

194.   D. A. Butterfield, S. M. Yatin, S. Varadarajan and T. Koppal, "Amyloid b-Peptide-Induced Oxidative Pathways of Cell Death," Methods Enzymology, 309 , 746-768 (1999).

193.   C. M. Lauderback, M. E. Harris-White, Y. Wang, N. W. Pedigo, Jr., J. M. Carney and D. A. Butterfield, "Amyloid b-Peptide Inhibits Na +-Dependent Glutamate Uptake," Life Sciences , 65 , 1977-1981 (1999).

192.   D. A. Butterfield, B. Howard, S. Yatin, T. Koppal, J. Drake, K. Hensley, M. Aksenov, M. Aksenova, R. Subramaniam, S. Varadarajan, M. E. Harris-White, N. W. Pedigo, Jr. and J. M. Carney, "Elevated Oxidative Stress in Models of Normal Brain Aging and Alzheimer’s Disease," Life Sciences , 65 , 1883-1892 (1999).

191.   S. M. DeAtley, M. Y. Aksenov, M. V. Aksenova, B. Jordan, J. M. Carney and D. A. Butterfield, "Adriamycin-Induced Changes of Creatine Kinase Activity In Vivo and in Cardiomyocyte Culture," Toxicology, 134, 51-62 (1999).

190.   D. A. Butterfield, T. Koppal, R. Subramaniam and S. Yatin," Vitamin E as an Antioxidant/Free Radical Scavenger Against Amyloid b-Peptide-Induced Oxidative Stress in Neocortical Synaptosomal Membranes and Hippocampal Neurons in Culture: Insights into Alzheimer's Disease," Reviews in the Neurosciences , 10 , 141-149 (1999).

189.   J. Kanski, T. Koppal and D. A. Butterfield, "Investigation of Peroxynitrite Induced Oxidative Stress in Red Blood Cells Monitored by Luminol-Dependent Chemiluminescence," Analyt. Letts. , 32 , 1183-1192 (1999).

188.   S. M. Yatin, M. Aksenova, M. Aksenov and D. A. Butterfield, "Effect of Transglutaminase on Ab 1-40 Fibril Formation and Neurotoxicity," Alzheimer's Reports , 2 , 165-170 (1999).

187.   T. Koppal, J. Drake and D. A. Butterfield, " In-Vivo Modulation of Rodent Glutathione and Its Role In Peroxynitrite-Induced Neocortical Synaptosomal Membrane Protein Damage," Biochimica et Biophysica Acta , 1453 , 407-411 (1999).

186.   M. Y. Aksenov, H. M. Tucker, P. Nair, S. Estus, M. V. Aksenova, D. A. Butterfield and W. R. Markesbery, "The Expression of Several Mitochondrial and Nuclear Genes Encoding the Subunits of Electron Transport Chain Enzyme Complexes, Cytochrome c Oxidase and NADH Dehydrogenase, in Different Brain Regions in Alzheimer’s Disease," Neurochem. Res. , 24 , 767-774 (1999).

185.   S. M. Yatin, M. Yatin, T. Aulick, K. B. Ain and D. A. Butterfield, "Alzheimer’s Amyloid b-Peptide Generated Free Radicals Increase Rat Embryonic Neuronal Polyamine Uptake and ODC Activity: Protective Effect of Vitamin E," Neuroscience Letts. , 263 , 17-20 (1999).

184.   D. A. Butterfield, "Alzheimer's Amyloid- b Peptide and Free Radical Oxidative Stress," In: Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach , (D. L. Gilbert and C. A. Colton, Eds.), Plenum Press, New York, 1999, pp. 609-638.

183.   M. V. Aksenova, M. Y. Aksenov, R. M. Payne, J. Q. Trojanowski, J. M. Carney, D. A. Butterfield and W. R. Markesbery, "Oxidation of Cytosolic Proteins and Expression of Creatine Kinase BB in Frontal Cortex in Different Neurodegenerative Disorders," Dementia and Geriatric Cognitive Disorders , 10 , 158-165 (1999).

182.   S. M. DeAtley, M. Y. Aksenov, M. V. Aksenova, B. Harris, R. Hadley, P. C. Harper, J. M. Carney and D. A. Butterfield, "Antioxidants Protect Against Reactive Oxygen Species Associated with Adriamycin-Treated Cardiomyocytes," Cancer Letters, 136, 41-46 (1999).

181.   S. M. Yatin, M. Aksenov and D. A. Butterfield, "The Antioxidant Vitamin E Modulates Amyloid b-Peptide-Induced Creatine Kinase Activity Inhibition and Increased Protein Oxidation: Implications for the Free Radical Hypothesis of Alzheimer’s Disease," Neurochem. Res. , 24 , 427-435 (1999).

180.   T. Koppal, J. Drake, S. Yatin, B. Jordan, S. Varadarajan, L. Bettenhausen and D. A. Butterfield, "Peroxynitrite-Induced Alterations in Synaptosomal Membrane Proteins: Insight Into Oxidative Stress in Alzheimer’s Disease," J. Neurochemistry , 72 , 310-317 (1999).

179.   S. M. Yatin, M. Aksenova, M. Aksenov, W. R. Markesbery, T. Aulick and D. A. Butterfield, "Temporal Relations Between Amyloid b-Peptide-Induced Free Radical Oxidative Stress and Neuronal Toxicity and Neuronal Defensive Responses," J. Molec. Neuroscience , 11 , 183-197 (1999).

178.   M. Y. Aksenov, H. M. Tucker, P. Nair, M. V. Aksenova, D. A. Butterfield, S. Estus and W. R. Markesbery, "The Expression of Key Oxidative Stress Handling Genes in Different Brain Regions in Alzheimer’s Disease," J. Molec. Neuroscience , 11 , 151-154 (1998).

177.   S. Ganapathi-Desai, D. A. Butterfield and D. Bhattacharyya, "Kinetics and Active Fraction Determination of a Protease Enzyme Immobilized on Functionalized Membranes: Mathematical Modeling and Experimental Results," Biotechnology Prog. , 14 , 865-873 (1998).

176.   D. A. Butterfield, T. Koppal, B. Howard, R. Subramaniam, N. Hall, K. Hensley, S. Yatin, K. Allen, M. Aksenov, M. Aksenova and J. Carney, "Structural and Functional Changes in Proteins Induced by Free Radical-Mediated Oxidative Stress and Protective Action of the Antioxidants N-tert-butyl- " -phenylnitrone (PBN) and Vitamin E," Ann. N. Y. Acad. Sci. , 854 , 448-462 (1998).

175.   S. Vishwanath, J. Wang, L. G. Bachas, D. A. Butterfield and D. Bhattacharyya, "Site-Directed and Random Immobilization of Subtilisin on Functionalized Membranes: Activity Determination in Aqueous and Organic Media," Biotech. & Bioeng. , 60 , 608-616 (1998).

174.   R. Subramaniam, T. Koppal, M. Green, S. Yatin, B. Jordan and D. A. Butterfield, "The Free Radical Antioxidant Vitamin E Protects Cortical Synaptosomal Membrane Proteins from Amyloid b-Peptide (25-35) Toxicity But Not from Hydroxynonenal Toxicity: Relevance to the Free Radical Hypothesis of Alzheimer's Disease," Neurochem. Res. , 23 , 1403-1410 (1998).

173.   J. G. Begley, D. A. Butterfield, J. N. Keller, T. Koppal, J. Drake and M. P. Mattson, "Preserved Plasma Membrane Glucose and Glutamate Transporter Activities, Membrane Protein Structure, and Mitochondrial Function in Cryopreserved Neocortical Synaptosomes," Brain Res., Brain Res. Protocols , 3 , 76-82 (1998).

172.   M. Y. Aksenov, M. V. Aksenova, W. R. Markesbery and D. A. Butterfield, "Amyloid b-Peptide(1-40) - Mediated Oxidative Stress in Cultured Hippocampal Neurons: Protein Carbonyl Formation, CK BB Expression and the Level of Cu, Zn and Mn SOD mRNA," J. Molec. Neuroscience , 10 , 181-192 (1998).

171.   S. M. DeAtley, M. Y. Aksenov, M. V. Aksenova, J. M. Carney and D. A. Butterfield, "Adriamycin Induces Protein Oxidation in Erythrocyte Membranes," Pharmacol. Toxicol. , 83 , 62-68 (1998).

170.   S. P. Gabbita, R. Subramaniam, F. Allouch, J. M. Carney and D. A. Butterfield, "Effects of Mitochondrial Respiratory Stimulation on Membrane Lipids and Proteins: An Electron Paramagnetic Resonance Investigation," Biochim. Biophys. Acta , 1372 , 163-173 (1998).

169.   T. Koppal, R. Subramaniam, J. Drake, M. R. Prasad and D. A. Butterfield, "Vitamin E Protects Against Amyloid Peptide (25-35)-Induced Changes in Neocortical Synaptosomal Membrane Lipid Structure and Composition," Brain Res. , 786 , 270-273 (1998).

168.   M. N. Aksenova, M. Y. Aksenov, J. M. Carney and D. A. Butterfield, "Protein Oxidation and Enzyme Activity Decline in Old Brown Norway Rats Are Reduced by Dietary Restriction," Mech. Ageing Develop. , 100 , 157-168 (1998).

167.   A. J. Bruce-Keller, J. G. Begley, W. Fu, D. A. Butterfield, D. E. Bredesen, J. B. Hutchins, K. Hensley and M. P. Mattson, "Bcl-2 Protects Isolated Plasma and Mitochondrial Membranes Against Lipid Peroxidation Induced by Hydrogen Peroxide and Amyloid b-Peptide," J. Neurochem. , 70 , 31-39 (1998).

166.   M. Y. Aksenov, M. V. Aksenova, J. M. Carney and D. A. Butterfield, "Oxidative Modification of Glutamine Synthetase by Amyloid Beta Peptide," Free Radical Res. , 27 , 267-281 (1997).

165.   R. Subramaniam, F. Roediger, B. Jordan, M. P. Mattson, J. N. Keller, G. Waeg and D. A. Butterfield, "The Lipid Peroxidation Product, 4-Hydroxy-2-Trans-Nonenal, Alters the Conformation of Cortial Synaptosomal Membrane Proteins," J. Neurochem. , 69 , 1161-1169 (1997).

164.   S. P. Gabbita, D. A. Butterfield and J. Carney, "Neurodegeneration and Potential Antioxidant Based Therapeutic Aproaches," in Mitochondria and Free Radicals in Neurodegenerative Diseases , (M. F. Beal, N. Howell and I. Bodis-Wollner, Eds.), 1997, pp. 497-512.

163.   D. A. Butterfield and E. R. Stadtman, "Protein Oxidation Processes in Aging Brain," Adv. Cell Aging Gerontol. , 2 , 161-191 (1997).

162.   S. P. Gabbita, K. Hensley, D. A. Butterfield and J. M. Carney, "Aging and Caloric Restriction Affect Mitochondrial Respiration and Lipid Membrane Status: An Electron Paramagnetic Resonance Investigation," Free Radical Biology & Medicine , 23 , 191-201 (1997).

161.   D. A. Butterfield, K. Hensley, P. Cole, R. Subramaniam, M. Aksenov, M. Aksenova, P. M. Bummer, B. E. Haley and J. M. Carney, "Oxidatively-Induced Structural Alteration of Glutamine Synthetase Assessed by Analysis of Spin Labeled Incorporation Kinetics: Relevance to Alzheimer's Disease," J. Neurochem. , 68 , 2451-2457 (1997).

160.   D. A. Butterfield, R. Subramaniam, P. S. Cole, S. Yatin, K. Hensley, N. C. Hall and J. M. Carney, "Electron Paramagnetic Resonance Studies of Amyloid b-Peptide- and Ischemia/-Reperfusion-Associated Oxygen Free Radicals and the Membrane Damage They Cause: Relevance to Alzheimer's Disease and Stroke," in Oxygen Radicals and the Disease Process , (C. E. Thomas and B. Kalyanaraman, Eds.), Harwood Academic Publishers, Reading, Great Britain, 1997, pp. 41-64.

159.   D. A. Butterfield, "b-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease," Chem. Res. Toxicol. , 10 , 495-506 (1997).

158.   D. A. Butterfield, R. Subramaniam, D. Bhattacharyya, S. Viswanath, W. Huang and L. Bachas, "Biofunctional Membranes: Electron Paramagnetic Resonance Studies of the Active Site Structure of Enzymes Site-Specifically Immobilized onto Polymeric Supports Through Molecular Recognition," Polymeric Materials Science and Engineering Preprints , 76 , 602-603 (1997).

157.   N. C. Hall, J. M. Carney, O. J. Plante, M. Cheng and D. A. Butterfield, "Effect of 2-Cyclohexene-1-one-Induced Glutathione Diminution on Ischemia/Reperfusion-Induced Alterations in the Physical State of Brain Synaptosomal Membrane Proteins and Lipids," Neuroscience , 77 , 283-290 (1997).

156.   D. A. Butterfield, B. J. Howard, S. Yatin, K. L. Allen and J. M. Carney, "Free Radical Oxidation of Brain Proteins in Accelerated Senescence and Its Modulation by N-Tert-Butyl- " -Phenylnitrone," Proc. Nat. Acad. Sci. USA , 94 , 674-678 (1997).

155.   P. S. Cole, M. E. Harris, J. M. Carney, N. C. Hall and D. A. Butterfield, "Methods of Evaluating Protein Oxidation Induced by Ischemia/Reperfusion Injury," in Primer on Cerebrovascular Diseases , (K. M. A. Welch, L. R. Caplans, D. J. Reis, B. K. Seisjo and B. Weir, Eds.), Academic Press, New York, 1997, pp. 205-206.

154.   P. S. Cole, N. C. Hall, J. M Carney, O. J. Plante and D. A. Butterfield, "Free Radical Oxidative Stress and Membrane Alterations in Ischemia/Reperfusion Injury," Recent Res. Develop. in Neurochem. , 1 , 99-109 (1996).

153.   M. Aksenov, M. Aksenova, J. M. Carney and D. A. Butterfield, "Alpha 1-Antichymotrypsin Interaction with Ab(1-42) Does Not Inhibit Fibril Formation But Altenuates the Peptide Toxicity," Neuroscience Letts. , 217 , 117-120 (1996).

152.   D. A. Butterfield, K. Hensley, N. Hall, R. Subramaniam, B. J. Howard, P. Cole, S. Yatin, M. La Fontaine, M. E. Harris, M. Aksenova, M. Aksenov and J. M. Carney, "b-Amyloid-Derived Free Radical Oxidation: A Fundamental Process in Alzheimer's Disease," in Molecular Models of Dementia , (W. Wasco and R. E. Tanzi, Eds.), Humana Press, Totowa, New Jersey, 1996, pp. 145-167.

151.   B. J. Howard, S. Yatin, K. Hensley, K. L. Allen, J. P. Kelly, J. Carney and D. A. Butterfield, "Prevention of Hyperoxia-Induced Alterations in Synaptosomal Membrane-Associated Proteins by N-Tert-Butyl- " -Phenylnitrone (PBN) and 4-Hydroxy-2,2,6,6-Tetramethylpiperidine-1-Oxyl (Tempol)," J. Neurochem. , 67 , 2045-2050 (1996).

150.   W. J. Clerici, K. Hensley, D. L. DiMartino and D. A. Butterfield, "Direct Detection of Ototoxicant-Induced Reactive Oxygen Species Generation in Cochlear Explants," Hearing Res. , 98 , 116-124 (1996).

149.   A. Bhardwaj, J. Lee, K. Glauner, S. Ganapathi, D. Bhattacharyya and D. A. Butterfield, "Biofunctional Membranes: An EPR Study of Active Site Structure and Stability of Papain Non-Covalently Immobilized on the Surface of Modified Poly (Ether) Sulfone Membranes Through the Avidin-Biotin Linkage," J. Membrane Sci. , 119 , 241-252 (1996).

148.   D. A. Butterfield, "Alzheimer's Disease: A Disorder of Oxidative Stress," Alzheimer's Disease Rev. , 1 , 68-70 (1996).

147.   M. E. Harris, Y. Wang, N. W. Pedigo, Jr., K. Hensley, D. A. Butterfield and J. M. Carney, "Ab(25-35) Inhibits Na +-Dependent Glutamate Uptake in Rat Hippocampal Astrocyte Cultures," J. Neurochemistry , 67 , 277-286 (1996).

146.   J. M. Carney, N. C. Hall, M. Cheng, J. Wu and D. A. Butterfield, "Protein and Lipid Oxidation Following Ischemia/Reperfusion Injury, the Role of Polyamines: An Electron Paramagnetic Resonance Analysis," Adv. Neurol. , 71 , 259-270 (1996).

145.   R. Subramaniam, P. Cole, K. Hensley, S. Azhar, P. Bummer, J. M. Carney and D. A. Butterfield, "Effects of Oxidative Stress on the Model Thiol Protease-Papain: An Investigation of Changes in Activity and Structure," Biochemical Arch. , 12 , 105-116 (1996).

144.   M. V. Aksenova, M. Y. Aksenov, D. A. Butterfield and J. M. Carney, "Alpha 1-Antichymotrypsin Interaction with Ab(1-40) Inhibits Fibril Formation But Does Not Affect the Peptide Toxicity," Neuroscience Letts. , 211 , 45-48 (1996).

143.   K. Hensley, D. A. Butterfield, N. Hall, P. Cole, R. Subramaniam, R. Mark, M. P. Mattson, W. R. Markesbery, M. E. Harris, M. Aksenov, M. Aksenova, J. F. Wu and J. M. Carney, "Reactive Oxygen Species as Causal Agents in the Neurotoxicity of the Alzheimer's Disease-Associated Amyloid Beta Peptide," Ann. N.Y. Acad. Sci. , 786 , 120-134 (1996).

142.   M. Y. Aksenov, M. V. Aksenova, D. A. Butterfield, K. Hensley, C. Vigo-Pelfrey and J. M. Carney, "Glutamine Synthetase-Induced Enhancement of β-Amyloid Peptide Aβ(1–40) Neurotoxicity Accompanied by Abrogation of Fibril Formation and Aβ Fragmentation," J. Neurochem. , 66 , 2050-2056 (1996).

141.   R. Subramaniam and D. A. Butterfield, "Structure-Activity Correlation of Subtilisin Immobilized on Modified Poly (Ether) Sulfone Membrane by Covalent and Non-Covalent Linkages," in Biofunctional Membranes , (D. A. Butterfield, Ed.), Plenum Press, New York, 1996, pp. 201-208.

140.   A. Bhardwaj, J. Lee, K. Glauner, D. Bhattacharyya and D. A. Butterfield, "Non-Covalent Immobilization of Papain Onto Modified Polysulfone Membrane Using Avidin-Biotin Coupling: EPR and Kinetic Studies," in Biofunctional Membranes , (D. A. Butterfield, Ed.), Plenum Press, New York, 1996, pp. 193-200.

139.   J. Lee, D. Bhattacharyya and D. A. Butterfield, "A Comparative Study of the Structural and Kinetic Properties of Papain Immobilized on Modified Polysulfone and Modified Cellulose Acetate Membranes," in Biofunctional Membranes , (D. A. Butterfield, Ed.), Plenum Press, New York, 1996, pp. 131-140.

138.   D. Bhattacharyya, S. Ganapathi, S. Vishwanath, M. Summers and D. A. Butterfield, "Immobilized Enzyme Reactions On Beads and Membranes," in Biofunctional Membranes, (D. A. Butterfield, Ed.), Plenum Press, New York, 1996, pp. 117-129.

137.   D. A. Butterfield, "Biofunctional Membranes," Plenum Press, New York, (1996).

136.   A. A. Houdi, S. Kottayil, P. A. Crooks and D. A. Butterfield, "3-O-Acetylmorphine-6-O-Sulfate: A Potent Centrally-Acting Morphine Derivative," Pharmacol. Biochem. Behav. , 53 , 665-671 (1996).

135.   C. P. Brock, S. Kottayil, D. A. Butterfield and P. A. Crooks, "A Dihydromorphine-6-O-sulfate," Acta Cryst. , C52 , 122-125 (1996).

134.   E. A. Decker, W. K. M. Chan, S. A. Livisay, D. A. Butterfield and C. Faustman, "Interactions Between Carnosine and the Different Redox States of Myoglobin," J. Food Sci. , 60 , 1201-1204 (1996).

133.   D. A. Butterfield, L. Martin, J. M. Carney and K. Hensley, "A b (25-35) Peptide Displays H 2O 2-Like Reactivity Towards Aqueous Fe 2+, Nitroxide Spin Probes, and Synaptosomal Membrane Proteins," Life Sciences , 58 , 217-228 (1996).

132.   D. A. Butterfield, "Membrane Cytoskeletal Protein Alterations in Alzheimer's Disease," in Non-Neuronal Cells in Alzheimer's Disease , (P. Zatta and M. Nicolini, Eds.), World Scientific Publishing Co., London, 1995, pp. 78-94.

131.   R. Subramaniam, B. J. Howard, K. Hensley, M. Aksenova, J. M. Carney and D. A. Butterfield, "b-Amyloid (32-35) Generates Reactive Free Radicals That Are Toxic to Biomolecules: Implications to Alzheimer's Disease," Alzheimer's Research , 1 , 141-144 (1995).

130.   C. H. Trad, W. James, A. Bhardwaj and D. A. Butterfield, "Selective Labeling of Membrane Protein Sulfhydryl Groups with Methanethiosulfonate Spin Label," J. Biochem. Biophys. Meth. , 30 , 287-299 (1995).

129.   S. Ganapathi, D. A. Butterfield and D. Bhattacharyya, "Flat Sheet and Hollow Fiber Membrane Bioreactors: A Study of the Kinetics and Active Site Conformational Changes of Immobilized Papain Including Sorption Studies of Reaction Constituents," J. Chem. Technol. Biotechnol. , 64 , 157-164 (1995).

128.   N. C. Hall, J. M. Carney, M. Cheng and D. A. Butterfield, "Prevention of Ischemia/Reperfusion-Induced Alterations in Synaptosomal Membrane-Associated Proteins and Lipids by N-tert-butyl- " -phenylnitrone and Difluoromethylornithine," Neuroscience , 69 , 591-600 (1995).

127.   M. E. Harris, J. M. Carney, P. Cole, K. Hensley, B. J. Howard, L. Martin, P. Bummer, Y. Wang, N. Pedigo and D. A. Butterfield, "b-Amyloid Peptide-Derived, Oxygen-Dependent Free Radicals Inhibit Glutamate Uptake in Cultured Astrocytes: Implications to Alzheimer's Disease," Neuro Report , 6 , 1875-1879 (1995).

126.   K. Hensley, N. Hall, R. Subramaniam, P. Cole, M. Harris, M. Aksenov, M. Aksenova, S. P. Gabbita, J. F. Wu, J. M. Carney, M. Lovell, W. R. Markesbery and D. A. Butterfield, "Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation," J. Neurochem. , 65 , 2146-2156 (1995).

125.   A. Alvarado, D. A. Butterfield, B. A. Watkins, B. H. Chung and B. Hennig, " Electron Spin resonance studies of fatty acid-induced alterations in membrane fluidity in cultured endothelial cells," Int. J. Biochem. Molec. Biol. , 27 , 665-673 (1995).

124.   M. Y. Aksenov, M. V. Aksenova, M. E. Harris, K. Hensley, D. A. Butterfield and J. M. Carney, "Enhancement of β-Amyloid Peptide Aβ(1–40)-Mediated Neurotoxicity by Glutamine Synthe," J. Neurochem. , 65 , 1899-1902 (1995).

123.   N. C. Hall, R. J. Dempsey, J. M. Carney, D. L. Donaldson and D. A. Butterfield, "Structural Alterations in Synaptosomal Membrane-Associated Proteins and Lipids by Transient Middle Cerebral Artery Occulusion in the Cat," Neurochem. Res. , 20 , 1161-1169 (1995).

122.   K. Hensley, D. A. Butterfield, M. Aksenova, M. Harris, J. Wu, R. Floyd, M. Mattson and J. M. Carney, "A Model for b -Amyloid Aggregation and Neurotoxicity Based on the Free Radical Generating Capacity of the Peptide: Implications of Peptide-Derived Free Radicals to Alzheimer's Disease," Proc. Western Pharmacol. Soc. , 38 , 113-120 (1995).

121.   R. J. Mark, K. Hensley, D. A. Butterfield and M. P. Mattson, "Amyloid b -Peptide Impairs Ion-Motive ATPase Activities: Evidence for a Role in Loss of Neuronal Ca 2+ Homeostasis and Cell Death," J. Neurosci. , 15 , 6239-6249 (1995).

120.   K. Hensley, B. J. Howard, J. M. Carney and D. A. Butterfield, "Membrane Protein Alterations in Rodent Erythrocytes and Synaptosomes Due to Aging and Hyperoxia," Biochim. Biophys. Acta , 1270 , 203-206 (1995).

119.   M. E. Harris, K. Hensley, D. A. Butterfield, R. A. Leedle and J. M. Carney, "Direct Evidence of Oxidative Injury Produced by the Alzheimer's Amyloid Beta Peptide (1-40) in Cultured Hippocampal Neurons," Exp. Neurol. , 131 , 193-202 (1995).

118.   K. Hensley, M. Aksenova, J. M. Carney, M. Harris and D. A. Butterfield, "Amyloid b-Peptide Spin Trapping II: Evidence for Decomposition of the PBN Spin Adduct," Neuro Report , 6 , 493-496 (1995).

117.   K. Hensley, M. Aksenova, J. M. Carney, M. Harris and D. A. Butterfield, "Amyloid b-Peptide Spin Trapping I: Peptide Enzyme Toxicity Is Related to Free Radical Spin Trap Reactivity," Neuro Report , 6 , 489-492 (1995).

116.   M. P. Mattson, J. M. Carney and D. A. Butterfield, "Glycation: A Tombstone in AD?" Nature , 373 , 481 (1995).

115.   N. C. Hall, J. M. Carney, M. S. Cheng and D. A. Butterfield, "Ischemia/Reperfusion Induced Changes in Membrane Proteins and Lipids of Gerbil Cortical Synaptosomes," Neuroscience , 64 , 81-89 (1995).

114.   S. S. Bellary, K. W. Anderson, W. A. Arden and D. A. Butterfield, "Effect of Lipopolysaccharide on the Physical Conformation of the Erythrocyte Cytoskeletal Proteins," Life Sciences , 56 , 91-98 (1995).

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