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Dr. Cungen Zhang

Department of Pharmaceutical Chemistry
School of Pharmacy
University of Maryland, Baltimore
20 Penn Street, Baltimore, MD 21201

Email: cungen.zhang@gmail.com

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Click here to view to details of the research project in the past. In Baltimore, I work on protein-ligand interaction with Dr. Michael Shapiro.

Useful NMR manual-- Written by Cungen Zhang

I would like to thank Prof. Anne-Frances Miller and John Latern for the support in writing the manual.

One Dimensional NMR

• commonly used VNMR commands

• s2pul standard NMR

• calibating pw90

• T1 determination

• T2 determination

• Solvent suppression, presat

• Water suppression, shaped pulse, wet1d

• C-13 NMR and DEPT

• metal-protein NMR, weft sequence

• Zero Filling

Two Dimensional NMR

• Standard COSY experiment

• TOCSY Experiment

• gDQCOSY and 2D plotting

• NOESY 

• ROESY

• gHSQC

• gHMBC

Click here to go back to Prof. Anne-Frances Miller's webpage.

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NMR web book of Joseph Hornak entitled "The Basics of NMR" - highly recommended for beginners and experts in NMR!

There are some NMR animations.

• Stern-Gerlach Experiment
• NMR and the Periodic Table*
• Nuclear Precession and the Larmor Frequency*
• Precession of Magnetization in a One-Frequency FID
• Precession of Magnetization in a Two-Frequency FID
• NMR Parameters (Chemical Shift, J-Coupling, etc.)*
• J-Couplings (In depth examination)*
• Pulse Phases*
• T1 (spin-lattice or longitudinal) Relaxation*
• Field Gradients and Spin Echoes*
• Attached Proton Test*
• INEPT Pulse Sequence*
• 2D NMR analysis of saccharin*
• Dot Products and Vector Products  by W. Bauer, MSU

NMR Animations from ETH Zurich (animated gifs from Dr. Beat Meier's research group)

• Bloch decay - vector picture of the Bloch decay
• Bloch decay with fast T2
• Hahn echo - vector picture of the Hahn echo (Carr-Purcell)
• On-resonance single pulse and evolution - relaxation (T1 and T2) back to equilibrium
• Off-resonance pulse - off-resonance precession
• Off-resonance pulse, 2 sites
• Off-resonance single pulse and evolution - relaxation (T1 and T2) back to equilibrium
• Off-resonance single pulse and evolution for 2 sites
• Composite pulse, large
• Composite pulse, small

More NMR movies you might be interested.

• Bloch equation animation
• Bloch equation with a very short T2
• Bloch equation with a T2 > T1
• 90 degree pulse with evolution
• On-Resonance pulse
• Off-Resonance pulse
• Off-Resonance pulse with evolution
• Off-resonance pulse on two sites
• Off-resonance pulse on two sites with evolution
• Off-resonance pulse with spinlocking
• Adiabatic Inversion
• Inversion that is too fast to be adiabatic
• Composite Pulse, small angle error
• Composite Pulse, large angle error
• Hahn echo

Quicktime Movies

• 90x-90x Spin Echo
• 90x-180x Spin Echo
• 90x-180y Spin Echo
• T1 Inversion Recovery (nice picture of T1 and T2 together during acquisition period)
• On-resonance irradiation (in the rotating frame)
• Off-resonance irradiation (in the rotating frame)

Useful Links of NMR

1. Basics of NMR. http://web.chem.queensu.ca/FACILITIES/NMR/nmr/webcourse/

2. http://www.ch.ic.ac.uk/local/organic/nmr.html

3. http://www.nmrfam.wisc.edu/index.html

4. http://www.chem.ualberta.ca/~orglabs/spectroscopy/hnmr/review.html

5. http://www.stanford.edu/group/chem-NMR/nmrlinks.htm

Inversion-recovery exercise--Julianna

Click here to enter Julianna's webpage