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Department of Chemistry
University of Kentucky

Leonidas Bachas

Frank J. Derbyshire Professor of Chemistry (Analytical and Biological Chemistry)
Biosensor Research and Development


The main thrust of our research lies in the area of Bioanalytical Chemistry. Specifically, we are interested in the development of new polymer membrane-based sensors for detecting biochemically important molecules and ions. The development of micro-total analysis systems (µ-TAS) requires the coupling of microfluidics platforms with an appropriate detection system. The performance of µ-TAS that employ electroosmotic pumping is affected by changes in ionic strength, which limits their applicability in ion analysis. On the contrary, centrifugal pumping is not dependent on ionic strength. We are interesting in developing new methods to interface ion-optode chemistry with centrifugal microfluidics devices. In particular, sensing membranes of diameters in the micrometer domain are fabricated by using "microspotting" methods. These membranes consist of an ionophore and a chromoionophore within a photopolymerazible polymer. These microspot optodes are intergrated into the centrifugal microfluidics device, incorporating several ionophores to develop optode microarrays to simultaneously analyze various ions in complex samples.


 

 

Further details of Dr. Bachas' work are given on the Chemistry website.


The Department of Chemistry is in the College of Arts & Sciences at the University of Kentucky.
 

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